Receptor Activator of Nuclear Factor Kappa B (RANK) and Clinicopathological Variables in Endometrial Cancer: A Study at Protein and Gene Level

The system integrated by the receptor activator of nuclear factor kappa B (RANK) and its ligand, RANKL, modulates the role of hormones in the genesis and progression of breast tumors. We investigated whether the expression of RANK was related with clinicopathological features of primary endometrial tumors. Immunohistochemistry was used in an endometrial cancer tissue array containing samples from 36 tumors. The amount of RANK mRNA was examined in a tissue scan cDNA array containing cDNA from 40 tumors. Normal endometrium was examined for comparison. Immunohistochemical analyses showed that RANK expression was higher in malignant than in normal endometrium (p &lt

Efficacy and quality of life after 10 years of transobturator tape surgery for stress urinary incontinence

Somatometric and clinical cardiovascular risk factors in midlife and older women. A tale of four European countries

Ibandronic acid subsequent to raloxifene: Effect on bone metabolism and on cardiovascular risk factors

s / Maturitas 81 (2015) 144–190 161 Materials andmethods: This randomized double-blind clinical trialwas carried out inAhvaz (Iran) fromAugust toDecember 2010. Forty postmenopausal women with symptoms of vaginal atrophy were randomly allocated to two groups to take vaginal suppositories of either 5mg hyaluronic acid sodium salt (n=20) or 1mg vitamin E (n=20) for 8 weeks. The symptoms of vaginal atrophy were evaluated by a self-assessed 4-point scale and the composite score was determined as none, mild, moderate, and severe in four periods. Results: The results showed that the symptoms were relieved significantly in both groups (P<0.001). The relief of symptomswas significantly superior in t…

Biochar and Forage Peanut improve pastures: Evidence from a field experiment in Brazil

Pasturelands, often degraded, represent most of the converted lands globally. It is important to understand how different pasture management approaches can improve soil quality, increase feed production and farmer income. Here, the impact of different soil enhancers on soil quality and productivity of three cultivars of Brachiaria (Syn. Urochloa) forage grass is presented. Soil enhancers included: biochar - a carbon-rich product from biomass pyrolysis, moinha (local charcoal residue), traditional fertiliser containing nitrogen, phosphorus and potassium, lime, and forage peanut (Arachis pintoi cv. Amarillo). Considering the total biomass produced over the experiment (sum of four harvests), t…

Self-organising maps for the analysis of data from big cohorts. The case of the Spanish CARMEN cohort