0000000000330173

AUTHOR

Mariangela Russo

showing 3 related works from this author

A study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence.

2007

The literature on immunosenescence has focused mainly on T cell impairment. With the aim of gaining insight into B cell immunosenescence, we investigated the serum immunoglobulin levels in a cohort of 166 subjects (20-106 years). Serum IgG (and IgG subclasses) were quantified by the nephelometric technique, IgE by CAP system fluorescence enzyme immunoassay, and IgD by radial immunodiffusion (RID). There was an age-related increase of IgG and IgA; the IgG age-related increase was significant only in men, but IgG1 levels showed an age-related increase both in men and women, whereas IgG3 showed an age-related increase only in men. IgE levels remain unchanged, whereas IgD and IgM serum levels d…

Malemedicine.medical_specialtyT cellNaive B cellLongevityImmunoglobulinsImmunoglobulin EImmunoglobulin DGeneral Biochemistry Genetics and Molecular BiologyImmune systemHistory and Philosophy of ScienceInternal medicinemedicineHumansB cellAgedAged 80 and overB-LymphocytesbiologyGeneral NeuroscienceImmunosenescenceEndocrinologymedicine.anatomical_structureImmunologybiology.proteinFemaleAntibodyImmunologic MemoryBiomarkers
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Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily

2003

Abstract During atherogenesis, a critical role is played by intercellular communication via gap junctions, cell membrane channels linking the cytoplasmic compartments of adjacent cells. The component protein subunits of these channels, called connexin (Cx), belong to a multigene family. Cx37 is involved in growth, regeneration after injury and ageing of the endothelial cells, suggesting its role in atherosclerosis. The C1019 single nucleotide polymorphism (SNP) of Cx37 gene was associated with thickening of the carotid intima in Swedish men and was also associated with coronary artery disease in a Taiwanese population. On the other hand, in two more recent studies performed in male Japanese…

AdultGenetic MarkersMalemedicine.medical_specialtyPathologyGenotypeHeart diseasePopulationMyocardial InfarctionSingle-nucleotide polymorphismPolymerase Chain ReactionPolymorphism Single NucleotideGastroenterologyConnexinsCoronary artery diseaseGene FrequencyRisk FactorsInternal medicineOdds RatioHumansMedicineSNPMyocardial infarctioneducationSicilyRetrospective Studieseducation.field_of_studybusiness.industryIncidenceCase-control studyDNAOdds ratioMiddle Agedmedicine.diseasePhenotypeCardiology and Cardiovascular MedicinebusinessInternational Journal of Cardiology
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Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: a genetically determined defect of C4 influences immunological parameter…

2003

Abstract Subjects with certain HLA alleles have a higher risk of specific autoimmune diseases than those without these alleles. The 8.1 ancestral haplotype (AH) is a common Caucasoid haplotype carried by most people who type for HLA-B8,DR3. It is unique in its association with a wide range of immunopathological diseases. To gain insight into the identification of the mechanism(s) of disease susceptibility of 8.1 AH carriers, we have investigated the prevalence of circulating immune complexes and non-organ-specific autoantibodies in healthy carriers of the haplotype. The results show that carriers of 8.1 AH display both a significant increased prevalence of immune complexes and higher titers…

AdultMaleEnzyme-Linked Immunosorbent AssayHuman leukocyte antigenBiologyAutoimmune DiseasesHLA-B8 AntigenImmune systemHLA-DR3 AntigenAntigenGene FrequencyHLA AntigensGenetic predispositionmedicineHumansAlleleAllelesPharmacologyAutoimmune diseaseGeneticsHaplotypeAutoantibodyComplement C4General MedicineMiddle Agedmedicine.diseaseHaplotypesImmunologyFemaleBiomedicinepharmacotherapy = Biomedecinepharmacotherapie
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