0000000000330635

AUTHOR

Carlo Vergani

showing 3 related works from this author

Tumor necrosis-factor-alpha -308 A/G polymorphism is associated with age at onset of Alzheimer's disease.

2006

Abstract Pro-inflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their production have been shown to be associated with AD. Tumor necrosis factor (TNF)-α is an inflammatory cytokine involved in the local immune response occurring in the central nervous system of AD patients. Genetic variation could contribute to the risk of developing AD or influence the age at the onset of the disease. We genotyped 222 patients (152 women, 70 men; age range 60–87) and 240 non-demented age-matched healthy controls for TNF-α −308 G/A single nucleotide polymorphism (SNP). No significant differences …

MaleApolipoprotein EAgingGenotypemedicine.medical_treatmentSNPSingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideWhite PeopleAlzheimer DiseaseRisk FactorsGenotypecytokinemedicineHumansGenetic Predisposition to DiseaseAge of OnsetAlleleAgedAged 80 and overTumor Necrosis Factor-alphaalzheimer TNF polymorphisms age of onsetMiddle AgedAlzheimer's diseasemedicine.diseaseCytokineItalyinflammationImmunologyFemaleTumor necrosis factor alphaMED/09 - MEDICINA INTERNAAge of onsetAlzheimer's diseaseTNF-alphaDevelopmental Biology
researchProduct

Effects of aging on sensation of dyspnea and health-related quality of life in elderly asthmatics

2005

BACKGROUND AND AIMS: As the awareness of sensory stimuli is often impaired in older subjects, it has been hypothesized that the aging process may influence the perception of dyspnea. This study aimed at evaluating the aging-related difference in perception of spontaneously occurring dyspnea in adult asthmatics and at whether any such aging-related differences have an effect on the health-related quality of life (HRQOL). METHODS: 18 elderly asthmatics (EA) aged >65 years and 20 young asthmatics (YA) (age range 16-44 years) were recruited. In all subjects, 12-month asthma symptom score and respiratory function were recorded. Dyspnea was measured at rest by the Visual Analog Scale (VAS) and HR…

AdultMaleAgingmedicine.medical_specialtyAdolescentVisual analogue scaleHealth StatusStatistics as TopicSettore MED/10 - Malattie Dell'Apparato RespiratorioQuality of lifeSensationmedicineHumansRespiratory functionRespiratory systemAgedAsthmaHealth related quality of lifebusiness.industryAsthma symptomsmedicine.diseaseAsthmarespiratory tract diseasesDyspneaQuality of LifePhysical therapyFemaleGeriatrics and GerontologybusinessAging Clinical and Experimental Research
researchProduct

Sleep disorders in the elderly with and without chronic airflow obstruction: the SARA study

2003

Objectives: Our objectives were to test the hypothesis that, in the geriatric population, chronic airway obstruction is associated with a higher prevalence of sleep disturbances; to identify the main correlates of sleep disturbances, and to verify whether asthma and COPD patients have different patterns of sleep disturbances. Methods: The EPESE questionnaire was administered to 734 patients aged 65 years and over with asthma or chronic obstructive pulmonary disease (cases) and 1237 individuals of comparable age who were free of respiratory disease but not of other chronic conditions (controls). Four sleep disturbances were quantified: difficulty in falling asleep, nocturnal awakening, morni…

Sleep Wake DisordersMalemedicine.medical_specialtyNeuropsychological TestsSettore MED/10 - Malattie Dell'Apparato RespiratorioLogistic regressionSeverity of Illness IndexCognition DisorderPulmonary Disease Chronic ObstructivePhysiology (medical)Internal medicineSurveys and QuestionnairesmedicineHumansSurveys and QuestionnaireSleep Wake DisorderWakefulnessDepression (differential diagnoses)Bronchodilator AgentAsthmaMorningAgedSleep disorderDepressive Disorder Majorbusiness.industryRespiratory diseasemedicine.diseaseSleep in non-human animalsBronchodilator AgentsSpirometryPhysical therapyGeriatric Depression ScaleFemaleNeuropsychological TestNeurology (clinical)businessCognition DisordersHuman
researchProduct