0000000000331188

AUTHOR

Gerard Blasco

showing 3 related works from this author

Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metab…

2021

Gut: first published.

Male0301 basic medicine2312MicrobiologiaGut floraTranscriptomeMice0302 clinical medicineOverweight persons1506Gut MicrobiotaPrefrontal cortexhealth care economics and organizationsdigestive oral and skin physiologyGastroenterologyIntestins -- MalaltiesFecal Microbiota TransplantationMiddle AgedPersones obesesserotonin3. Good healthInhibition PsychologicalIntestins -- MicrobiologiaPhenotypemedicine.anatomical_structureintestinal microbiology ; microbiota ; obesity.ObesitatFemaleIntestines -- DiseasesdopamineperformanceAdultmedicine.medical_specialtytryptophan depletionPhysical exerciseBiologyIntestines -- Microbiologydigestive systemMicrobiologyAmino Acids Aromatic03 medical and health sciencesMetabolomicsInternal medicinemedicineAnimalsHumansObesityAnterior cingulate cortexAgedIntestinal microbiologyMetabolismbiology.organism_classificationCarbonGastrointestinal MicrobiomeFatty LiverCross-Sectional Studies030104 developmental biologyEndocrinologyTranscriptome030217 neurology & neurosurgeryStroop effect
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Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance

2021

[Background]: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms.

AdultMalemedicine.medical_specialtyDisbiosisEndocrinology Diabetes and MetabolismHypothalamusMedicine (miscellaneous)StriatumIntestines -- MicrobiologyArticleBody Mass IndexGlàndules endocrinesInternal medicineNeural PathwaysmedicineHumansObesityEndocrine glandsNutrition and DieteticsHipotàlembusiness.industryFunctional connectivityMiddle Agedmedicine.diseaseObesityIntestins -- MicrobiologiaCross-Sectional StudiesEndocrinologyHypothalamusStructural covarianceObesitatDysbiosisFemaleGut dysbiosisbusinessInsulaHypothalamic DiseasesExecutive dysfunction
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The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition, and Cognitive Function.

2017

Context Microbiota perturbations seem to exert modulatory effects on emotional behavior, stress-, and pain-modulation systems in adult animals; however, limited information is available in humans. Objective To study potential relationships among the gut metagenome, brain microstructure, and cognitive performance in middle-aged, apparently healthy, obese and nonobese subjects after weight changes. Design This is a longitudinal study over a 2-year period. Setting A tertiary public hospital. Patients or other participants Thirty-five (18 obese) apparently healthy subjects. Intervention(s) Diet counseling was provided to all subjects. Obese subjects were followed every 6 months. Main outcome me…

0301 basic medicineAdultMalemedicine.medical_specialtyWaistEndocrinology Diabetes and MetabolismIronClinical BiochemistryHippocampusFirmicutesContext (language use)BiologyNeuropsychological TestsBiochemistryAmygdala03 medical and health sciences0302 clinical medicineEndocrinologyCognitionInternal medicinemedicineImage Processing Computer-AssistedHumansEffects of sleep deprivation on cognitive performanceLongitudinal StudiesObesityBacteroidetesBiochemistry (medical)Case-control studyBrainCognitionMiddle AgedMagnetic Resonance ImagingGastrointestinal Microbiome030104 developmental biologyEndocrinologymedicine.anatomical_structureCross-Sectional StudiesCase-Control StudiesMetagenomeFemaleWaist CircumferenceBody mass index030217 neurology & neurosurgeryTenericutesThe Journal of clinical endocrinology and metabolism
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