6533b85afe1ef96bd12b95a4

RESEARCH PRODUCT

Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance

Romina Miranda-olivosCarles Soriano-masCarles Soriano-masJ. PuigMaría Arnoriaga-rodríguezMaría Arnoriaga-rodríguezAndrés MoyaJ. Rivera-pintoGerard BlascoCarles BiarnesOren Contreras-rodríguezVicente Pérez-brocalClàudia CollJosé Manuel Fernández-realJosé Manuel Fernández-realLluís Ramió-torrentàM. L. Calle

subject

AdultMalemedicine.medical_specialtyDisbiosisEndocrinology Diabetes and MetabolismHypothalamusMedicine (miscellaneous)StriatumIntestines -- MicrobiologyArticleBody Mass IndexGlàndules endocrinesInternal medicineNeural PathwaysmedicineHumansObesityEndocrine glandsNutrition and DieteticsHipotàlembusiness.industryFunctional connectivityMiddle Agedmedicine.diseaseObesityIntestins -- MicrobiologiaCross-Sectional StudiesEndocrinologyHypothalamusStructural covarianceObesitatDysbiosisFemaleGut dysbiosisbusinessInsulaHypothalamic DiseasesExecutive dysfunction

description

[Background]: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms.

yearjournalcountryeditionlanguage
2021-09-01
10.1038/s41366-021-00953-9https://ddd.uab.cat/record/251205