0000000000456281
AUTHOR
J. Puig
Risk for non-AIDS-defining and AIDS-defining cancer of early versus delayed initiation of antiretroviral therapy
BACKGROUND: Immediate initiation of antiretroviral therapy (ART) regardless of CD4 cell count reduces risk for AIDS and non-AIDS-related events in asymptomatic, HIV-positive persons and is the standard of care. However, most HIV-positive persons initiate ART when their CD4 count decreases below 500 × 10 9 cells/L. Consequences of delayed ART on risk for non-AIDS-defining and AIDS-defining cancer, one of the most common reasons for death in HIV, are unclear. OBJECTIVE: To estimate the long-term risk difference for cancer with the immediate ART strategy.DESIGN: Multinational prospective cohort study.SETTING: The D:A:D (Data collection on Adverse events of anti-HIV Drugs) study, which included…
Observaciones sobre algunos criterios tafonómicos usados en la interpretación de asociaciones malacológicas fósiles.
In the present paper a revision of some taphonomic criteria commonly used in the interpretation of fossil mollusca assemblages is realized . The field work on living and death assemblages of mollusca in a shallow muddy bottom has been carried out in the coast near Denia (Alicante, Spain). Although the supposed lineal relation between specific abundance and probability of autochthony could explain the structure of part of the considered assemblages, in other a clear disagreement due to a massive incursion of youth elements in observed . By other hand, the possibility of horizontal transport not detectable by these means (anonymous alochtonic fluxes) imposes another limitation to the pretende…
Tranexamic acid in cardiac surgery: Are low doses enough?
OBJECTIVES Tranexamic acid is used to prevent hyperfibrinolysis and reduce postoperative bleeding and blood transfusions in on-pump cardiac surgery. We evaluate the efficacy of low or high dose tranexamic acid in a prospective cohort study conducted in Valencia. MATERIALS AND METHODS A total of 427 patients were recruited between January 2019 and January 2020, 207 in the Hospital General Universitario (low dose [LD]) and 220 in the Hospital Universitario y Politecnico La Fe (high dose [HD] and intermediate dose [ID]). We recorded the presence of hyperfibrinolysis on rotational thromboelastometry, intra- and postoperative administration of blood products, chest tube output within the first 1…
Ácido tranexámico en cirugía cardíaca: ¿las dosis bajas son suficientes?
Resumen Objetivos El acido tranexamico se utiliza para prevenir la hiperfibrinolisis y disminuir el sangrado postoperatorio y el empleo de hemoderivados en cirugia cardiaca con circulacion extracorporea. Este trabajo evalua la eficacia de dosis bajas o altas de acido tranexamico mediante un estudio de cohortes, prospectivo, realizado en 2 hospitales de Valencia. Material y metodos Se seleccionaron 427 pacientes, 207 en el Hospital General Universitario (dosis bajas [DB]) y 220 en el Hospital Universitario y Politecnico La Fe (dosis intermedias [DI] y dosis altas [DA]), entre enero de 2019 y enero de 2020. Se estudio la presencia de hiperfibrinolisis por tromboelastometria rotacional, la adm…
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
[Background]: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms.
Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome : a Randomized Clinical Trial
Importance The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain. Objective To determine if lung recruitment associated with PEEP titration according to the best respiratory-system compliance decreases 28-day mortality of patients with moderate to severe ARDS compared with a conventional low-PEEP strategy. Design, Setting, and Participants Multicenter, randomized trial conducted at 120 intensive care units (ICUs) from 9 countries from November 17, 2011, through April 25, 2017, enrolling adults with moderate to severe ARDS. Interventions An experimental strat…