0000000000320108
AUTHOR
María Arnoriaga-rodríguez
showing 17 related works from this author
Additional file 2 of Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
2020
Additional file 2. Alignments of the mimetic amino acid motif of the α-MSH, the ClpB from E. coli str K12 and the predicted ORFs from each sequence of the samples 1, 30 and 143.
Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
[Background]: Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut microbiota and the potential role of the microbiome in influencing sex steroid hormones and shaping sexually dimorphic susceptibility to disease have been largely overlooked. Although there is some evidence of sex-specific differences in the gut microbiota diversity, composition, and functionality, the results are inconsistent. Importantly, most of these studies have not taken into account the go…
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
2021
[Background]: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms.
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metab…
2021
Gut: first published.
Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
2020
[Background]: The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations of gut bacterial ClpB-like gene function with obesity status and gut microbiota in humans.
Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function.
2022
Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery (n = 114) and replication cohorts (n = 942). We also found that Blastocystis was linked to bacterial functions related to aromatic amino acids metabolism and folate-mediated pyrimidine and one-carbon metabolism. Blastocystis-associated shifts in bacterial functionality translated into …
Additional file 1 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 1: Supplementary Table 1. Clinical characteristics of subjects after 1-year follow-up according to the gender and menopausal status.
Additional file 5 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 5: Supplementary Table 5. MRM parameters for determination of steroids and isotopically labelled standards by LC–MS/MS.
Additional file 3 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 3: Supplementary Table 3. DESeq2 results for the differential expressed bacterial taxa between post-menopausal women and men.
Additional file 2 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 2: Supplementary Table 2. DESeq2 results for the differential expressed bacterial taxa between pre-menopausal women and men.
Additional file 6 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 6: Supplementary Figure 1. Associations of gut microbiota composition in non-obese and obese subjects and bacterial families with gender and menopause status. Alpha diversity indices in a) non-obese and b) obese individuals. Beta diversity in non-obese subjects measured by c)Bray-Curtis and d) weighted unifrac. Beta diversity in obese subjects measured by e) Bray-Curtis and f) weighted unifrac. Overall differences in the microbiome composition among groups were assessed by PERMANOVA using 1000 permutations and pairwise differences between groups were assessed using the pairwise.adonis function adjusted for Bonferroni correction. *,P < 0.05; **, P < 0.01.g) Volcano plot…
Additional file 4 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 4: Supplementary Table 4. DESeq2 results for the differential expressed bacterial taxa between pre-menopausal women and post-menopausal women.
Additional file 1 of Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
2020
Additional file 1. Top 10 bacterial taxa (family level) contributing reads to the gut bacterial ClpB-like function, in absolute and relative figures per sample.
Additional file 7 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 7: Supplementary Figure 2. Associations of gut microbiota functionality with gender and menopause status in non-obese subjects. a) Fold change for the significant differential KEGG pathways between pre-menopausal women and men, and b) pre- and post-menopausal women, identified by DESeq2 adjusting for age and obesity status. Bars are colored according to the Benjamini-Hochberg corrected p values (pFDR).
Additional file 8 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 8: Supplementary Figure 3. Gender and menopausal status differences in gonadal steroids according to the obesity status. Boxplots for the concentrations of progestin,androgens, and estrogens converted to base 10 logarithmic values. Differences among groups were analyzed by a Kruskal-Wallis test, and pair-wise comparisons were assessed by the Wilcoxon test. Significant differences are highlighted in bold italics.
Additional file 3 of Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
2020
Additional file 3. Alignments. Alignment motif of the α-MSH and percentage of identity between the E. coli motif and the identified microbial counterparts in each sequence. Bacterial family identity: Average identity of the epitope in each bacterial family compared to the motif in E. coli as well as the distribution of families through the samples according to their degree of homology.
Additional file 9 of Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
2020
Additional file 9: Supplementary Figure 4. Gut microbial associations with circulating testosterone concentrations. a) Permutation tests for the goodness-of-fit (R2Y) and goodness of prediction (Q2Y) for the O-PLS model predicting plasma testosterone levels from bacterial families in non-obese individuals. b) Significant gut bacterial families identified by O-PLS modeling. c) Permutation tests for the goodness-of-fit (R2Y) and goodness of prediction (Q2Y) for the O-PLS model predicting plasma testosterone levels after 1-year follow-up from bacterial families at baseline in humans. d) Significant gut bacterial families identified by O-PLS modeling. e) Permutation tests for the goodness-of-fi…