6533b7d9fe1ef96bd126cefb

RESEARCH PRODUCT

Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile

Andrés MoyaAurelijus BurokasAurelijus BurokasVicente Pérez-brocalMaría Arnoriaga-rodríguezRafael MaldonadoJordi Mayneris-perxachsManuel Portero-otinJosé Manuel Fernández-realWifredo Ricart

subject

MaleRikenellaceaeGut floraPrevotellaceaemedicine.disease_causeFecesMice0302 clinical medicineOverweight personsClostridiaceae2. Zero hunger0303 health sciencesIntestins -- MalaltiesEndopeptidase ClpFecal Microbiota TransplantationMiddle AgedPersones obeses3. Good healthIntestins -- Microbiologialcsh:QR100-130FemaleIntestines -- DiseasesAdultMicrobiology (medical)medicine.medical_specialtyFirmicutesBiologyIntestines -- Microbiologydigestive systemMicrobiologylcsh:Microbial ecology03 medical and health sciencesInternal medicinemedicineAnimalsHumansMicrobiomeObesityBacterial gene functionEscherichia coliAged030304 developmental biologyBacteriaResearchBacterial gene function ; Body weight regulation ; Microbiome ; Obesitybiology.organism_classificationGastrointestinal MicrobiomeMice Inbred C57BLCross-Sectional StudiesEndocrinologyCase-Control StudiesBody weight regulationMicrobiomeCLPB030217 neurology & neurosurgery

description

[Background]: The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations of gut bacterial ClpB-like gene function with obesity status and gut microbiota in humans.

yearjournalcountryeditionlanguage
2020-04-30
10.1186/s40168-020-00837-6http://hdl.handle.net/10261/220869