0000000000331548
AUTHOR
Juan C. Jimenez
Baseline factors affecting closure of venous leg ulcers
Objective: The objective of this study was to characterize factors associated with closure of venous leg ulcers (VLUs) in a pooled analysis of subjects from three randomized clinical trials. Methods: Closure of VLUs after treatment with HP802-247, an allogeneic living cell therapy consisting of growth-arrested human keratinocytes and fibroblasts, vs standard therapy with compression bandaging was evaluated in three phase 3 clinical trials of similar design. Two trials enrolled subjects with VLUs ranging from 2 cm2 to 12 cm2 in area with 12-week treatment periods; the third trial enrolled subjects with VLUs between >12 cm2 and #36 cm2 with a 16-week treatment period. The first trial went to …
Supplementary Figures from Spatio-temporal patterns of thermal anomalies and drought over tropical forests driven by recent extreme climatic anomalies
The recent 2015–2016 El Niño (EN) event was considered as strong as the EN in 1997–1998. Given such magnitude, it was expected to result in extreme warming and moisture anomalies in the tropical land. Here we characterize the spatial patterns of temperature anomalies and drought over tropical forests, including tropical South America (Amazonia), Africa and Asia/Indonesia during the 2015–2016 EN event. These spatial patterns of warming and drought are compared with those observed in previous strong EN events (1982–1983 and 1997–1998) and other moderate to strong EN events (e.g. 2005–05 and 2009–10). The link between the spatial patterns of drought and sea surface temperature anomalies in the…