0000000000337567
AUTHOR
V Esposito
Pre-ART HIV-1 DNA in CD4+ T cells correlates with baseline viro-immunological status and outcome in patients under first-line ART
Objectives We evaluated the association between pre-ART HIV DNA and HIV-infected participant characteristics at baseline as well as with their response to first-line ART. Methods Four hundred and thirty-three patients from the ICONA cohort, starting first-line ART after the year 2000, were analysed. Pre-ART HIV DNA was quantified with the modified COBAS TaqMan HIV-1 Test and normalized by CD4+ T cells. Linear correlation between pre-ART HIV DNA and other continuous markers (HIV RNA, CD4 count, markers of inflammation and coagulation) at baseline was evaluated by means of Pearson correlation coefficient and a linear regression model. Survival analyses and Cox regression models were used to s…
Incidence and risk factors for liver enzyme elevation among naive HIV-1-infected patients receiving ART in the ICONA cohort
AbstractObjectivesTo evaluate the incidence and risk factors for liver enzyme elevations (LEE) in patients initiating first-line ART in the ICONA prospective observational cohort, between June 2009 and December 2017.Patients and methodsIn total, 6575 ART-naive patients were selected, initiating two NRTIs with the third drug being a boosted PI (n=2436; 37.0%), an NNRTI (n=2384; 36.3%) or an integrase strand transfer inhibitor (INSTI) (n=1755; 26.7%). HBV surface antigen and HCV RNA were detected in 3.9% and 5.8% of the study population. Inverse probability weighted Cox regression analysis was used to calculate the HRs, according to first-line regimen, for LEE, defined as ALT or AST increases…
Pediatric selective mutism and sleep disorders: A pilot restrospective case control-study
Introduction: Selective mutism (SM) is characterized by the persistent inability to speak in some specific contexts (i.e. school, home, social contexts) or within interaction with peer group and/or adults when a normal verbal linguistic competence may be expected, according to DSM5 criteria. The main sleep disorders in children with neurodevelopmental disorders are represented by difficulty in falling asleep at night (51%) and nocturnal awakenings (67%).The main goal of the present study is verify the putative relationship between sleep disorders and selective mutism in children.Materials and methods: 30 children were diagnosed with SM (13 males and 17 females) with mean age 9.47 (SD +/- 12…