0000000000337971
AUTHOR
Guillermo Jorques
Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.
Legionella pneumophila is a strictly environmental pathogen and the etiological agent of legionellosis. It is known that non-vertical processes have a major role in the short-term evolution of pathogens, but little is known about the relevance of these and other processes in environmental bacteria. We report the whole-genome sequencing of 69 L. pneumophila strains linked to recurrent outbreaks in a single location (Alcoy, Spain) over 11 years. We found some examples where the genome sequences of isolates of the same sequence type and outbreak did not cluster together and were more closely related to sequences from different outbreaks. Our analyses identify 16 recombination events responsibl…
Source Detection in an Outbreak of Legionnaire’s Disease
Spatial statistics have broadly been applied, developed and demanded from the field of epidemiology. The point process theory is an appropriate framework to analyse the spatial variation of risk of disease from information at individual level.