Author: M.-f Vernevaut

0000000000338368

AUTHOR

M.-f Vernevaut

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Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver

2001

The effects of a water-soluble extract (WSE) of rosemary and its purified antioxidant rosmarinic acid (RA) on xenobiotic metabolizing enzymes (XME) were studied in rat liver after dietary administration. The modulation of phase I enzymes such as cytochrome P450 (CYP) 1A, 2B, 2E1, 3A, and phase II enzymes such as glutathione S-transferase (GST), quinone reductase (QR) and UDP-glucuronosyltransferase (UGT) was evaluated by measuring enzyme activities with specific substrates. Protein levels of CYPs and rGST A1/A2, A3/A5, M1, M2 and P1 were measured using antibodies in Western blots. Caffeic acid was also studied because it results from RA biotransformation in rat after oral administration. Ma…

MaleAntioxidantmedicine.medical_treatment[SDV]Life Sciences [q-bio]ReductaseToxicologychemistry.chemical_compoundCytosol0302 clinical medicine[SDV.IDA]Life Sciences [q-bio]/Food engineeringCaffeic acidChromatography High Pressure LiquidComputingMilieux_MISCELLANEOUSchemistry.chemical_classification0303 health sciencesbiologyRosmarinic acidOrgan SizeGeneral Medicine[SDV.IDA] Life Sciences [q-bio]/Food engineeringStimulation Chemical3. Good health[SDV] Life Sciences [q-bio]LiverBiochemistry030220 oncology & carcinogenesisMicrosomes Liver[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process EngineeringImmunoblottingDepsidesdigestive systemFlavonesXenobiotics03 medical and health sciencesmedicineAnimals[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringRats Wistar030304 developmental biologyFlavonoidsLamiaceaePlant ExtractsTerpenesBody WeightROMARINCytochrome P450GlutathioneDietRatsEnzymechemistryCinnamatesbiology.proteinRATSpectrophotometry UltravioletBiomarkersFood Science

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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SHSocial Sciences and Humanities
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