0000000000340291
AUTHOR
Roberta Riccaboni
Behavioral genetics of suicidality in Bipolar Disorder: the interaction between SERT and CLOCK polymorphisms and early-life stress
Il suicidio è un problema di salute pubblica sottostimato, così come è un lutto almeno parzialmente prevenibile: ogni contributo alla conoscenza dei fattori di rischio ad esso associati possono aiutare lo sviluppo di interventi terapeutici efficaci rivolti a fasce vulnerabili della popolazione. Più del 90% delle persone che si suicidano, o provano a farlo, hanno una malattia psichiatrica diagnosticabile e circa il 60% di tutte le morti per suicidio si verificano nel contesto di un disturbo dell’umore, soprattutto di tipo bipolare. Il suicidio ha oltretutto alta familiarità: la suicidalità è ereditabile, indipendentemente dalla diagnosi associata. Lo stress è un fattore di rischio sia prossi…
Patterns of evidence integration in schizophrenia and delusion.
Previous studies documented a bias against disconfirmatory evidence (BADE) in patients affected by schizophrenia spectrum disorders, with some discrepant findings on its relationship with delusions. In order to further investigate the patterns of evidence integration in schizophrenia and delusion, we recruited 40 deluded and non-deluded patients with schizophrenia and 40 healthy control subjects. Participants were administered the BADE test, which consisted of 30 delusion-neutral scenarios, each one progressively described by three subsequent disambiguating statements and providing four types of interpretation to rate for plausibility; at every additional evidence presentation, participants…
Self-awareness of cognitive functioning in schizophrenia: Patients and their relatives
"Cognitive impairment has been recognized since the earliest descriptions of schizophrenia as a core feature of the illness and different programmes have been developed to remediate these deficits. In all likelihood it is important for compliance and adherence to treatment that not only the patients but also their relatives be aware of the patients; cognitive deficits. Sixty-two patients with a diagnosis of schizophrenia and, for each one of them, one family member and an informant from the medical staff, were recruited and administered the Schizophrenia Cognition Rating Scale (SCoRS) ratings. Patients were tested for cognitive deficits with a neuropsychological battery and their performanc…
Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences
Background. Despite behavioural signs of flattened affect, patients affected by schizophrenia show enhanced sensitivity to negative stimuli. The current literature concerning neural circuitry for emotions supports dysregulations of cortico-limbic networks, but gives contrasting results. Adverse childhood experiences (ACEs) could persistently influence emotional regulation and neural correlates of response to emotional stimuli in healthy humans. This study evaluated the effect of ACEs and chronic undifferentiated schizophrenia on neural responses to emotional stimuli (negative facial expression). Method. Brain blood-oxygen-level-dependent functional magnetic resonance imaging neural response…