Rapport final du projet Antibiotools - Des outils pour caractériser et suivre les antibiotiques et antibiorésistances dans les écosystèmes aquatique (PNREST Anses, 2017/3 ABR/22)

Résistance aux antibiotiques et impact écologique chez les communautés microbiennes benthiques exposées a la contamination urbaine.

National audience

Multiple tools for antibiotics and AMR characterisation in aquatic ecosystems a 2-years monitoring study

International audience

Exposure of benthic microbial communities to pharmaceuticals and resulting adaptation including tolerance, biodegradation and antibiotic resistance: advances and challenges

International audience; Since the early 1920’s, pharmaceuticals, including antibiotics, have been massively producedand consumed for the benefit of both human and animal health. Pharmaceuticals residues havethen reached the aquatic environment through diffuse and point (wastewater) sources. Amongthe pharmaceutical residues, the ubiquitous presence of antibiotics could exert a selectivepressure on microbial communities leading to the acquisition and dissemination of antibioticresistance in the environment.We present here the synthesis of recent research projects (e.g. PANDORE, Antibio-tools,Antibiotox, PharmaTox...) investigating the dissemination of pharmaceuticals, includingantibiotics, in…

The impact of urban contamination on antibioresistance in microbial communities from periphyton and sediments

International audience; Since the early 20's antibiotics have been massively produced and consumed for the benefit of bothhuman and animal health. Nevertheless, antibiotics have also reached the aquatic environmentthrough diffuse sources (e.g. veterinary treatment, contaminated manure application...) and throughwastewater. Consequently, antibiotics concentrations between the ng/L and μg/L range are regularlydetected in surface water and those molecules have also been found in sediments and aquatic biota.The ubiquitous presence of antibiotics exerts a selective pressure on microbial communities leading tothe acquisition and dissemination of antibioresistance in the environment. While both an…