Brief S2k guidelines - Merkel cell carcinoma

Jurgen C. Becker, Chalid Assaf, Dirk Vordermark, Sven N. Reske, Jorg Hense, Therese Dettenborn, Oliver Seitz, Stephan Grabbe (1) Division of General Dermatology, Graz University Hospital, Austria (2) Department of Dermatology, HELIOS Klinikum, Krefeld, Germany (3) Department of Radiotherapy, University Hospital Halle (Saale), Germany (4) Department of Nuclear Medicine, University Hospital Ulm, Germany (5) Department of Internal Medicine, University Hospital Essen, Germany (6) Department of Plastic Surgery, Hornheide Clinic, Munster, Germany (7) Department of Oral and Maxillofacial Surgery, University of Frankfurt Hospital, Germany (8) Department of Dermatology, Mainz University Hospital, Ge…

A Novel Allylic Anchor for Solid-Phase Synthesis—Synthesis of Protected and Unprotected O-Glycosylated Mucin-Type Glycopeptides

HYCRON, an Allylic Anchor for High-Efficiency Solid Phase Synthesis of Protected Peptides and Glycopeptides

The recently developed allylic HYCRON anchor1 exhibits excellent properties for the solid phase synthesis of protected peptides and glycopeptides. Model reactions with analogous low molecular weight compounds assessed the acid- and base-stability of the polar and flexible HYCRON linkage. The new anchor is available in a two-step synthesis and allows the use of both the Boc- and the Fmoc-strategy, which can even be combined within one synthesis. Protected glycopeptides are released under almost neutral conditions, taking advantage of the Pd(0)-catalyzed allyl transfer to a weakly basic nucleophile such as N-methylaniline. The highly efficient synthesis of O-αGalNAc(TN)-peptides of the MUC-1 …