0000000000341837

AUTHOR

G. Abate

showing 2 related works from this author

Randomized, double-blind, placebo controlled, multicentre study of idebenone in patients suffering from multi-infarct dementia

1992

Abstract In this randomized double-blind, placebo controlled, multicentre study on 108 elderly patients with mild to moderate mental deterioration of vascular origin, idebenone — a benzoquinone derivative with a hydroxyalkyl side chain — proved to be therapeutically effective in the treatment of multi-infarct dementia. The oral administration of idebenone 45 mg/day b.i.d. for 120 days significantly improved the scores of the following test in comparison with placebo: Mini Mental State, Randt Memory Test, Gottfries Rating Scale, Token Test, Toulouse Pieron Test, indicating improvements in memory attention and cognitivity. The drug was well tolerated and effective in patients with multi-infar…

Agingmedicine.medical_specialtyHealth (social science)Vascular diseaseCerebral infarctionbusiness.industrymedicine.diseasePlaceboClinical trialOral administrationRating scaleAnesthesiamedicinePhysical therapyIdebenoneDementiaGeriatrics and GerontologybusinessGerontologymedicine.drugArchives of Gerontology and Geriatrics
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Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGA…

2007

Objectives To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects. Methods The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activiti…

GerontologyMalemedicine.medical_specialtyActivities of daily livingSettore MED/25 - PSCHIATRIAComorbidityNeuropsychological Testsbehavioral disciplines and activitiesDisability EvaluationMental ProcessesRating scaleExecutive functionmental disordersmedicine80 and overHumansEffects of sleep deprivation on cognitive performanceCognitive performanceAgedGeriatricsCognitive evaluation theoryAged 80 and overDepressive DisorderCognitive disorderActivities of daily livingMild cognitive impairmentCognitionmedicine.diseaseComorbidityActivities of daily living; Cognitive performance; Comorbidity; Executive function; Mild cognitive impairment; Activities of Daily Living; Aged; Aged 80 and over; Amnesia; Comorbidity; Depressive Disorder; Disability Evaluation; Female; Humans; Male; Mental Processes; Neuropsychological Tests; Geriatrics and Gerontology; Psychiatry and Mental HealthPsychiatry and Mental HealthSettore MED/26 - NeurologiaFemaleactivities of the day livingAmnesiaGeriatrics and GerontologyPsychologyhuman activities
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