6533b7d9fe1ef96bd126cbf9
RESEARCH PRODUCT
Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project.
E. MarianiR. MonasteroS. ErcolaniP. RinaldiF. MangialascheE. CostanziD. F. VitaleU. SeninP MecocciC. GabelliA. CodemoK. MarinelliA. CapursoD. CucinottaA. ReggianiL. EllenaO. ZanettiP. PutzuM. Del PreteS. SpaccamentoG. AbateA. Di IorioA. CesterM. FormilanF. BusoneraF. AnzivinoG. MasottiC. CavalliniE. MosselloP. OdettiA. G. CataldiM. PippiA. EstraneoG. SicaS. RennaVittorio Nicita MauroGiorgio BasileG. SalvioliC. MussiS. AscariR. CasaleG. FrazzittaM. ScognamiglioA. Di PalmaF. RengoV. CanonicoF. FortunatoG. EnziM. GiordanoT. Vitrano CataniaE. FerrariG. CuzzoniM. L. Del ReG. GuizzardiC. BiaginiA. BavazzanoA. FerrariA. DallariP. CarboninR. BernabeiM. C. SilveriL. BartorelliB. GandolfiR. CerquaA. PilottoL. CascavillaA. ChiarantiM. MarinelliG. TripiM. GallucciC. MarchettiV. MasielloD. SaccoG. Riccisubject
GerontologyMalemedicine.medical_specialtyActivities of daily livingSettore MED/25 - PSCHIATRIAComorbidityNeuropsychological Testsbehavioral disciplines and activitiesDisability EvaluationMental ProcessesRating scaleExecutive functionmental disordersmedicine80 and overHumansEffects of sleep deprivation on cognitive performanceCognitive performanceAgedGeriatricsCognitive evaluation theoryAged 80 and overDepressive DisorderCognitive disorderActivities of daily livingMild cognitive impairmentCognitionmedicine.diseaseComorbidityActivities of daily living; Cognitive performance; Comorbidity; Executive function; Mild cognitive impairment; Activities of Daily Living; Aged; Aged 80 and over; Amnesia; Comorbidity; Depressive Disorder; Disability Evaluation; Female; Humans; Male; Mental Processes; Neuropsychological Tests; Geriatrics and Gerontology; Psychiatry and Mental HealthPsychiatry and Mental HealthSettore MED/26 - NeurologiaFemaleactivities of the day livingAmnesiaGeriatrics and GerontologyPsychologyhuman activitiesdescription
Objectives To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects. Methods The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activities of Daily Living (IADL) scale. Comorbidity was evaluated by the Cumulative Illness Rating Scale (CIRS). Cognitive evaluation included tests assessing episodic memory, language, attention/executive functioning and praxis, as well as the the Mini-Mental State Examination (MMSE) as a measure of global cogniton. Results Subjects with aMCI had higher IADL changes than NCI. Among IADL items, aMCI subjects showed a significant impairment in shopping, taking drugs, and handling economy; however also NCI had minor IADL changes regarding cooking, washing and cleaning. IADL restriction in aMCI subjects was significantly associated with cognitive performance, mainly related to executive functioning, but not with comorbidity. On the contrary, in NCI sensory impairment accounts for slight IADL changes. Conclusion In aMCI subjects a mild degree of cognitive deterioration has a stronger impact on IADL than somatic comorbidity. Current diagnostic criteria for MCI should include a mild impairment in IADL. Copyright © 2007 John Wiley & Sons, Ltd.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-12-07 |