0000000000342516

AUTHOR

A. Maurizio Vignola

showing 4 related works from this author

Airway inflammation in nonasthmatic amateur runners

2001

Elite athletes show a high prevalence of symptoms and signs of asthma, but no study has assessed the acute effects of endurance exercise on airway cells in nonasthmatic athletes. We measured exhaled nitric oxide (NO) and collected samples of induced sputum after 3% NaCl aerosol administration for 20 min in nonasthmatic middle-aged amateur runners after the Fourth Palermo International Marathon and 6–9 wk later (habitual training period) at baseline. After the marathon, exhaled NO ( n = 9 subjects) was higher [27 ± 9 parts/billion (ppb)] than at baseline (12 ± 4 ppb; P < 0.0005). Polymorphonuclear neutrophil (PMN) counts in induced sputum were much higher in runners (91.2 ± 3.6% of total…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyNeutrophilsPhysiologyMacrophage-1 AntigenPhysical exerciseNitric OxideRunningLeukocyte CountReference ValuesEndurance trainingPhysiology (medical)Internal medicinemedicineHumansL-SelectinBronchitisAsthmaBlood CellsbiologyAthletesbusiness.industryRespirationRespiratory diseaseSputumAirway inflammationCell BiologyMiddle Agedmedicine.diseasebiology.organism_classificationRespiratory Function TestsBloodCD18 AntigensPhysical therapyAirwaybusinesshuman activitiesAmateur
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Circulating hematopoietic progenitor cells in runners

2002

Because endurance exercise causes release of mediators and growth factors active on the bone marrow, we asked whether it might affect circulating hematopoietic progenitor cells (HPCs) in amateur runners [ n = 16, age: 41.8 ± 13.5 (SD) yr, training: 93.8 ± 31.8 km/wk] compared with sedentary controls ( n = 9, age: 39.4 ± 10.2 yr). HPCs, plasma cortisol, interleukin (IL)-6, granulocyte colony-stimulating factor (G-CSF), and the growth factor fms-like tyrosine kinase-3 (flt3)-ligand were measured at rest and after a marathon (M; n = 8) or half-marathon (HM; n = 8). Circulating HPC counts (i.e., CD34+cells and their subpopulations) were three- to fourfold higher in runners than in controls at b…

AdultMalemedicine.medical_specialtyMarathonTime FactorsHydrocortisonePhysiologymedicine.medical_treatmentPhysical Therapy Sports Therapy and RehabilitationAntigens CD34Settore MED/10 - Malattie Dell'Apparato RespiratorioSettore BIO/09 - FisiologiaRunningEndocrinologyReference ValuesEndurance trainingPhysiology (medical)Internal medicineGranulocyte Colony-Stimulating FactormedicineHumansOrthopedics and Sports MedicineProgenitor cellCytokineBlood CellsPhysical Education and TrainingHematopoietic cellInterleukin-6business.industryGrowth factorMembrane ProteinsGrowth factorMiddle AgedHematopoietic Stem CellsEndurance trainingBlood Cell CountCytokinemedicine.anatomical_structureEndocrinologyembryonic structuresImmunologyPhysical EnduranceHematopoietic progenitor cellsBone marrowCytokines; Endurance training; Growth factors; Marathon; Physiology; Endocrinology; Orthopedics and Sports Medicine; Physical Therapy Sports Therapy and Rehabilitationbusinesshuman activities
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Effects of inhaled corticosteroids, leukotriene receptor antagonists, or both, plus long-acting beta2-agonists on asthma pathophysiology: a review of…

2004

Chronic inflammation and smooth muscle dysfunction are consistent features of asthma, and are responsible for disease progression and airway remodelling. The development of chronic airway inflammation depends upon the recruitment and activation of inflammatory cells and the subsequent release of inflammatory mediators, including cytokines. Cellular and histological evaluation of drugs with anti-inflammatory activity, such as inhaled corticosteroids (ICSs), is achieved by analysing samples of lung tissue or biological fluids, obtained by techniques such as bronchial biopsy, bronchoalveolar lavage and sputum induction. These provide valuable information on the inflammatory processes occurring…

Pathophysiology of asthmamedicine.drug_classInflammationAdrenal Cortex HormonesBronchodilatorAdministration InhalationmedicineHumansPharmacology (medical)Adrenergic beta-2 Receptor AgonistsAsthmaLungmedicine.diagnostic_testLeukotriene receptorbusiness.industryNebulizers and Vaporizersmedicine.diseaseAsthmarespiratory tract diseasesmedicine.anatomical_structureBronchoalveolar lavageDelayed-Action PreparationsImmunologyLeukotriene AntagonistsBronchoconstrictionDrug Therapy CombinationReceptors Adrenergic beta-2medicine.symptombusinessDrugs
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Airway cells after swimming outdoors or in the sea in nonasthmatic athletes

2003

BONSIGNORE, M. R., G. MORICI, L. RICCOBONO, M. PROFITA, A. BONANNO, A. PATERNO, R. DI GIORGI, L. CHIMENTI, P. ABATE, F. MIRABELLA, A. M. VIGNOLA, and G. BONSIGNORE. Airway Cells after Swimming Outdoors or in the Sea in Nonasthmatic Athletes. Med. Sci. Sports Exerc., Vol. 35, No. 7, pp. 1146–1152, 2003. Marathon runners and elite swimmers showed increased inflammatory cells in the airways at baseline. Although airway neutrophils increase further after a marathon race, the airway response to swimming is unknown. The aim of this study was to assess the effects of swimming on airway cells. To avoid the concomitant effects of chronic exposure to chlorine, the study was conducted in seven nonasth…

AdultSpirometrymedicine.medical_specialtyAdolescentRespiratory SystemPhysical Therapy Sports Therapy and RehabilitationNitric OxideNeutrophil ActivationRunningEndurance trainingInternal medicinemedicineHumansOrthopedics and Sports MedicineExpirationRespiratory systemSwimmingInflammationEosinophil cationic proteinmedicine.diagnostic_testbusiness.industryrespiratory systemEosinophilRespiratory Function Testsrespiratory tract diseasesSurgerymedicine.anatomical_structureEndocrinologyBreath TestsExhaled nitric oxidePhysical EndurancebusinessAirway
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