0000000000343362

AUTHOR

Chiara Cosma

showing 4 related works from this author

Definition of the upper reference limit of glycated albumin in blood donors from Italy.

2017

Abstract Background: Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. Methods: The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The upper reference limit (URL) was calculated using the non-parametric percentile method. Results: A modest, although significant, increase of GA was observed in relation to age (p<0.001), especially in ma…

AdultGlycation End Products AdvancedMalemedicine.medical_specialtyPercentileAdolescentClinical BiochemistryPopulationSerum albuminEnzyme Assay030209 endocrinology & metabolismBlood Donors030204 cardiovascular system & hematology03 medical and health sciencesYoung Adult0302 clinical medicineGlycated albuminReference ValuesInternal medicineDiabetes mellitusmedicineblood donors; diabetes; glycated albumin; reference limit; Adolescent; Adult; Aged; Enzyme Assays; Female; Humans; Italy; Male; Middle Aged; Reference Values; Serum Albumin; Young Adult; Blood Donors; Clinical Biochemistry; Biochemistry (medical)HumansReference ValueGlycated Serum AlbuminYoung adulteducationSerum AlbuminGlycemicAgedEnzyme Assayseducation.field_of_studydiabetesbiologyBlood Donorbusiness.industryBiochemistry (medical)General MedicineMiddle Agedreference limitmedicine.diseaseLarge sampleItalydiabetebiology.proteinglycated albuminFemalebusinessHumanClinical chemistry and laboratory medicine
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Glycated albumin is correlated to insulin resistance and β-cell secretory function in subjects at risk for developing diabetes

2018

Insulin resistance and β-cell secretory function represent two main issues in the pathogenesis of type 2 diabetes mellitus (T2DM). Conflicting results have been obtained about the association between glycated albumin (GA) and body mass index (BMI), insulin resistance and β-cell function in diabetic patients. Actually, the relationship (if any) between GA and the markers of glucose homeostasis and insulin resistance in subjects at risk of developing diabetes, has not been completely elucidated yet. Two hundred and one patients undergoing to oral glucose tolerance test (OGTT) were enrolled in the study. Routine laboratory tests, including fasting insulin, were performed at enrollment. GA was …

glycated albumin insulin resistance diabetes β-cellSettore BIO/12 - Biochimica Clinica E Biologia Molecolare ClinicaSettore MED/13 - Endocrinologia
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Clinical usefulness of Glycated Albumin in the diagnosis of diabetes: Results from an Italian study

2018

Objectives: Glycated Albumin (GA) has been proposed as a screening marker for diabetes in Asian countries in the last years. Nevertheless, few studies have been conducted in Caucasian population. The aim of this study is to evaluate the clinical usefulness of GA in diabetes diagnosis in Caucasian asymptomatic subjects considered at risk of diabetes based on medical history and Fasting Plasma Glucose (FPG). Design and methods: Three hundred and thirty-four Caucasian subjects having one or more risk factor for diabetes, and/or FPG ranging from 5.6 mmol/L to 6.9 mmol/L with no symptoms for diabetes were enrolled in this study. Plasma GA was measured by an enzymatic method (quantILab Glycated A…

AdultGlycation End Products AdvancedMalemedicine.medical_specialtyHbA1cClinical Biochemistry030209 endocrinology & metabolism030204 cardiovascular system & hematologyDiabeteAsymptomatic03 medical and health sciences0302 clinical medicineGlycated albuminGlycated albuminDiabetes mellitusInternal medicineDiabetes MellitusmedicineAsian countryHumansGlycated Serum AlbuminMedical historyRisk factorCaucasian populationSerum AlbuminDiabetes; Glycated albumin; HbA1c; Impaired fasting glucose; ROC curve; Screening; Clinical BiochemistryAgedGlycated Hemoglobinbusiness.industryDiabetesGeneral MedicineMiddle AgedImpaired fasting glucosemedicine.diseaseImpaired fasting glucoseROC curveItalyScreeningFemalemedicine.symptombusiness
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Glycated albumin as a glycaemic marker in patients with advanced chronic kidney disease and anaemia: a preliminary report.

2019

BACKGROUND: The association between glycated albumin (GA) and glycaemic status has not been fully described in patients with advanced chronic kidney disease (CKD) in relation to anaemia. The aim of this study was to evaluate the relationship between GA and fasting plasma glucose (FPG) and HbA1c in patients with advanced CKD and to evaluate the influence of anaemia in such relationship. MATERIALS AND METHODS: Patients with CKD stage 4 or 5 were included in the study. eGFR was calculated by the CKD-EPI creatinine equation. Plasma GA was measured by an enzymatic method. RESULTS: Eighty-one patients were included in the study, 46 (57%) were males; the mean age was 67 ± 14 years. HbA1c was corre…

Blood GlucoseGlycation End Products AdvancedMalemedicine.medical_specialtyClinical Biochemistry030209 endocrinology & metabolism030204 cardiovascular system & hematologyGastroenterologyrenal insufficiency03 medical and health sciences0302 clinical medicineGlycated albuminPreliminary reportInternal medicinemedicineHumansIn patientGlycated Serum AlbuminRenal Insufficiency ChronicSerum AlbuminAgedGlycated Hemoglobinanaemiabusiness.industryAnemiaGeneral MedicineFastingmedicine.diseaseglycated haemoglobin ARegression AnalysisFemalebusinessBiomarkersKidney diseaseScandinavian journal of clinical and laboratory investigation
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