0000000000343819

AUTHOR

Katharina Bahr

showing 4 related works from this author

Intensity of Respiratory Cortical Arousals Is a Distinct Pathophysiologic Feature and Is Associated with Disease Severity in Obstructive Sleep Apnea …

2021

Background: We investigated whether the number, duration and intensity of respiratory arousals (RA) on C3-electroencephalographic (EEG) recordings correlate with polysomnography (PSG)-related disease severity in obstructive sleep apnea (OSA) patients. We also investigated if every patient might have an individual RA microstructure pattern, independent from OSA-severity. Methods: PSG recordings of 20 OSA patients (9 female

medicine.medical_specialtymicrostructurePolysomnographyArticleArousallcsh:RC321-57103 medical and health sciences0302 clinical medicinearousalInternal medicineRespiratory disturbance indexmedicinelcsh:Neurosciences. Biological psychiatry. NeuropsychiatrySleep Stagesmedicine.diagnostic_testbusiness.industryGeneral NeuroscienceSleep apneaApneamedicine.diseasesleep apnearespiratorysleep-disturbed breathingnervous system diseasesIntensity (physics)respiratory tract diseasesObstructive sleep apnea030228 respiratory systemCardiologymedicine.symptombusiness030217 neurology & neurosurgeryBrain Sciences
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PD-L1 Expression and Immune Cell Infiltration in Gastroenteropancreatic (GEP) and Non-GEP Neuroendocrine Neoplasms With High Proliferative Activity

2019

The potential of neuroendocrine neoplasms (NEN) to respond to checkpoint inhibitors is largely unknown and full of great expectations. Immunohistochemical (IHC) studies of programmed cell death ligand 1 (PD-L1) expression in the tumor microenvironment and its implications in predicting the response to checkpoint inhibition is a very active subject. Currently, the combined analysis of PD-L1 expression and tumor-associated immune cell (TAIC) infiltration is considered the best predictive marker of therapeutic response. Here we investigated the expression of PD-L1 on tumor cells (TC) and tumor-infiltrating immune cells (IC) by IHC in 68 NEN samples with a high proliferation rate (Ki-67 >20%…

0301 basic medicinePD-L1Cancer ResearchCD3immune checkpoint inhibitorBiologyNeuroendocrine tumorslcsh:RC254-28203 medical and health sciences0302 clinical medicineImmune systemPD-L1tumor associated immune cellmedicineT cell infiltrationOriginal ResearchTumor microenvironmentneuroendocrine neoplasmCD68neuroendocrine carcinomamedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens030104 developmental biologyOncology030220 oncology & carcinogenesisCancer researchbiology.proteinImmunohistochemistryCD8neuroendocrine tumorFrontiers in Oncology
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Corticoperipheral neuromuscular disconnection in obstructive sleep apnoea.

2020

Abstract The roles of central nervous mechanisms and cortical output in obstructive sleep apnoea remain unclear. We addressed corticomuscular coupling between cortical sensorimotor areas and lower facial motor units as a mechanistic pathway and as a possible surrogate marker of corticoperipheral motor control in obstructive sleep apnoea. In this exploratory cross-sectional retrospective study, we analysed EEG (C3 and C4 leads) and chin EMG from polysomnography recordings in 86 participants (22 females; age range: 26–81 years): 27 with mild (respiratory disturbance index = 5–15 events/h), 21 with moderate (15–30 events/h) and 23 with severe obstructive sleep apnoea (>30 events/h) and 15 cont…

0301 basic medicinemedicine.medical_specialtyobstructive sleep apnoeacorticalPolysomnography03 medical and health sciences0302 clinical medicineInternal medicineRespiratory disturbance indexmedicinecouplingSleep Stagesmedicine.diagnostic_testbusiness.industryGeneral EngineeringMotor controlmedicine.diseasemotorMotor unitObstructive sleep apneaAutonomic nervous system030104 developmental biologyBreathingCardiologyOriginal Articleneuromuscularbusiness030217 neurology & neurosurgeryBrain communications
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The Apnea-Hypopnea Index Underestimates Systemic Inflammation in Women with Sleep-Disordered Breathing.

2018

Evidence suggests that sleep-related respiratory and related metabolic compromise may vary between females and males with sleep-disordered breathing (SDB). Our purpose was to elucidate possible gender differences in sleep-associated respiratory and inflammatory parameters in patients with SDB.A consecutive number of SDB patients (46 females and 167 males) who underwent polysomnography were retrospectively reviewed. Fibrinogen and C-reactive protein (CRP) concentration, apnea index (ApnI), hypopnea index (HypI), apnea-hypopnea index (AHI), average and minimal SpOApnI and AHI were significantly higher in males. Correlation analysis revealed striking gender differences: only in females, CRP co…

AdultMalemedicine.medical_specialtyPolysomnographyPolysomnography030204 cardiovascular system & hematologyBody Mass Index03 medical and health sciences0302 clinical medicineSleep Apnea SyndromesRisk FactorsInternal medicinemedicineHumansObesityAgedRetrospective StudiesInflammationSleep Apnea Obstructivebiologymedicine.diagnostic_testbusiness.industryC-reactive proteinSnoringApneaFibrinogenGeneral MedicineMiddle Agedmedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneaC-Reactive Protein030228 respiratory systemApnea–hypopnea indexCardiologyBreathingbiology.proteinFemalemedicine.symptombusinessHypopneaBody mass indexJournal of women's health (2002)
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