6533b873fe1ef96bd12d5948

RESEARCH PRODUCT

The Apnea-Hypopnea Index Underestimates Systemic Inflammation in Women with Sleep-Disordered Breathing.

Christoph JahnKatharina BahrChristoph MatthiasHaralampos GouverisPerikles Simon

subject

AdultMalemedicine.medical_specialtyPolysomnographyPolysomnography030204 cardiovascular system & hematologyBody Mass Index03 medical and health sciences0302 clinical medicineSleep Apnea SyndromesRisk FactorsInternal medicinemedicineHumansObesityAgedRetrospective StudiesInflammationSleep Apnea Obstructivebiologymedicine.diagnostic_testbusiness.industryC-reactive proteinSnoringApneaFibrinogenGeneral MedicineMiddle Agedmedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneaC-Reactive Protein030228 respiratory systemApnea–hypopnea indexCardiologyBreathingbiology.proteinFemalemedicine.symptombusinessHypopneaBody mass index

description

Evidence suggests that sleep-related respiratory and related metabolic compromise may vary between females and males with sleep-disordered breathing (SDB). Our purpose was to elucidate possible gender differences in sleep-associated respiratory and inflammatory parameters in patients with SDB.A consecutive number of SDB patients (46 females and 167 males) who underwent polysomnography were retrospectively reviewed. Fibrinogen and C-reactive protein (CRP) concentration, apnea index (ApnI), hypopnea index (HypI), apnea-hypopnea index (AHI), average and minimal SpOApnI and AHI were significantly higher in males. Correlation analysis revealed striking gender differences: only in females, CRP concentration was highly correlated with snoring duration (r = 0.4393), BMI (r = 0.7147), minimal SpORespiratory compromise in females with SDB is more strongly associated with systemic inflammation than in males with SDB. Although females display a pathological AHI less frequently than males, they reach quite similar pathological SaO

yearjournalcountryeditionlanguage
2018-07-01Journal of women's health (2002)
10.1089/jwh.2017.6819https://pubmed.ncbi.nlm.nih.gov/29630436