0000000000343938

AUTHOR

A. Shtauvere-brameus

showing 5 related works from this author

Microsatellite allele 5 of MHC class I chain-related gene a increases the risk for insulin-dependent diabetes mellitus in latvians.

2006

: Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases. It is an autoimmune, polygenic disease, associated with several genes on different chromosomes. The most important gene is human leukocyte antigen (HLA), also known as major histocompatibility complex (MHC), which is located on chromosome 6p21.3. HLA-DQ8/DR4 and DQ2/DR3 are positively associated with IDDM and DQ6 is negatively associated with IDDM in most Caucasian populations. The MICA gene is located in the MHC class I region and is expressed by monocytes, keratinocytes, and endothelial cells. Sequence determination of the MICA gene identifies 5 alleles with 4, 5, 6, and 9 repetitions of GCT or 5 repe…

Maleendocrine system diseasesAdolescentHuman leukocyte antigenMajor histocompatibility complexGeneral Biochemistry Genetics and Molecular BiologyHistory and Philosophy of ScienceGene FrequencyDiabetes mellitusHLA-DQ AntigensMHC class ImedicineHumansGenetic Predisposition to DiseaseAlleleChildGeneAllelesbiologyGeneral NeuroscienceHistocompatibility Antigens Class IInfant Newbornnutritional and metabolic diseasesChromosomeInfantmedicine.diseaseLatviaDiabetes Mellitus Type 1Child PreschoolImmunologybiology.proteinMicrosatelliteFemaleMicrosatellite RepeatsAnnals of the New York Academy of Sciences
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Microsatellite allele A5.1 of MHC class I chain-related gene A is associated with latent autoimmune diabetes in adults in Latvia.

2006

NIDDM is one of the most common forms of diabetes. The diagnosis is based on WHO classification, which is a clinical classification and misses the autoimmune diabetes in adults. Therefore, among the clinically diagnosed NIDDM cases, there can be a certain number of patients with latent autoimmune diabetes in adults (LADA). The MICA gene is located in the MHC class I region and is expressed by monocytes, keratinocytes, and endothelial cells. Sequence determination of the MICA gene identifies trinucleotide repeat (GCT) microsatellite polymorphism, which identifies 5 alleles with 4, 5, 6, and 9 repetitions of GCT (A4, A5, A6, and A9) or 5 repetitions of GCT with 1 additional G insertion for al…

AdultMaleGeneral Biochemistry Genetics and Molecular Biologylaw.inventionHistory and Philosophy of ScienceGene FrequencylawDiabetes mellitusMHC class ImedicineHumansGenetic Predisposition to DiseaseAlleleAge of OnsetPolymerase chain reactionAllelesbiologyGeneral NeuroscienceHistocompatibility Antigens Class Imedicine.diseaseLatviastomatognathic diseasesDiabetes Mellitus Type 2HaplotypesImmunologybiology.proteinMicrosatelliteFemaleAge of onsetAntibodyTrinucleotide repeat expansionMicrosatellite RepeatsAnnals of the New York Academy of Sciences
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Islet autoantibodies in Latvian subjects with non-insulin-dependent diabetes mellitus: slow-onset type 1 diabetes or polyendocrine autoimmunity?

2006

In Latvia diabetes mellitus is diagnosed using the WHO's clinical criteria; assays for the detection of autoantibodies are not available, and hence slowly progressive autoimmune diabetes is likely to be missed. Autoantibodies against glutamic acid decarboxylase (GAD65) and protein tyrosine phosphatase (IA-2) among patients with clinically diagnosed NIDDM identify group of patients with slow-onset type 1 diabetes or LADA. The aim of this study was to estimate the risk of polyendocrine autoimmunity among clinically diagnosed NIDDM patients from Latvia. One hundred NIDDM patients and 100 healthy controls were tested for GAD65 and IA-2 autoantibodies as well as 21-hydroxylase (21-OH) and tissue…

AdultMalemedicine.medical_specialtyendocrine system diseasesAdolescentTissue transglutaminasemedicine.medical_treatmentOverweightmedicine.disease_causeAutoantigensGeneral Biochemistry Genetics and Molecular BiologyAutoimmunityDiagnosis DifferentialHistory and Philosophy of ScienceInternal medicineDiabetes mellitusmedicineHumansReceptor-Like Protein Tyrosine Phosphatases Class 8ChildPolyendocrinopathies AutoimmuneAutoantibodiesProtein Tyrosine Phosphatase Non-Receptor Type 1Type 1 diabetesbiologybusiness.industryGlutamate DecarboxylaseGeneral NeuroscienceInsulinAutoantibodynutritional and metabolic diseasesMembrane Proteinsmedicine.diseaseLatviaIsoenzymesEndocrinologyDiabetes Mellitus Type 1Child Preschoolbiology.proteinFemalemedicine.symptomProtein Tyrosine PhosphatasesbusinessBody mass indexBiomarkersAnnals of the New York Academy of Sciences
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Tumor Necrosis Factor-α Allele 2 Shows an Association with Insulin-Dependent Diabetes Mellitus in Latvians

2006

Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases. It is an autoimmune disease. Genes contributing the most for development of IDDM are located on chromosome 6p21.3 in the region called the major histocompatibility complex (MHC). HLA-DQ8/DR4 and DQ2/DR3 have shown positive association with IDDM, while DQ6 has negative association with IDDM in most Caucasian populations. The location of the tumor necrosis factor alpha (TNF-alpha) gene in the MHC suggests the role of TNF in the etiology of IDDM as an autoimmune disease. The TNF region contains several polymorphisms that are associated with different levels of TNF-alpha production and susceptibility to autoi…

Maleendocrine systemmedicine.medical_specialtyAdolescentendocrine system diseasesDiseaseMajor histocompatibility complexPolymerase Chain ReactionGeneral Biochemistry Genetics and Molecular BiologyGene FrequencyHistory and Philosophy of Scienceimmune system diseasesDiabetes mellitusInternal medicinemedicineHumansGenetic Predisposition to DiseaseAlleleChildGeneAllelesAutoimmune diseasebiologyTumor Necrosis Factor-alphabusiness.industryGeneral NeuroscienceHistocompatibility Antigens Class IInfant NewbornInfantnutritional and metabolic diseasesmedicine.diseaseLatviaDiabetes Mellitus Type 1EndocrinologyChild Preschoolbiology.proteinEtiologyFemaleTumor necrosis factor alphabusinessMicrosatellite RepeatsAnnals of the New York Academy of Sciences
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Antibodies to New Beta Cell Antigen ICA12 in Latvian Diabetes Patients

2006

In Latvia diabetes mellitus is diagnosed using the WHO's clinical criteria, and assays for the detection of autoantibodies are not available. In consequence, slowly progressive autoimmune diabetes or LADA is likely to be missed. Antibodies to GAD65 and IA-2 are the major immunological markers in autoimmune diabetes. Recently, a new beta cell antigen, called ICA12, has been identified, which has a homology to the SOX family of transcription factors. The aim of the study was to analyze the prevalence of ICA12 antibodies in diabetes mellitus patients and controls from Latvia and to see whether this antigen is important in revealing autoimmunity when antibodies against major antigens are not pr…

Maleendocrine systemAdolescentendocrine system diseasesmedicine.disease_causeAutoantigensGeneral Biochemistry Genetics and Molecular BiologyAutoimmunityIslets of LangerhansHistory and Philosophy of ScienceAntigenHLA-DQ AntigensDiabetes mellitusmedicineHumansChildAutoantibodiesgeographygeography.geographical_feature_categorybiologyGlutamate Decarboxylasebusiness.industryGeneral NeuroscienceHigh Mobility Group ProteinsAutoantibodyInfantnutritional and metabolic diseasesmedicine.diseaseIsletLatviaIsoenzymesDiabetes Mellitus Type 2Child PreschoolAutoimmune diabetesImmunologybiology.proteinFemaleDisease SusceptibilityBeta cellAntibodybusinessSOXD Transcription FactorsBiomarkersAnnals of the New York Academy of Sciences
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