0000000000345390
AUTHOR
Hassan-ismail Hanser
showing 7 related works from this author
Perception des molécules chimiosensorielles en mélange : impact du métabolisme périphérique
2015
The chemosensory system is highly sensitive and discriminant. To ensure these properties, rapid and effective mechanisms are necessary to eliminate chemosensory molecules reaching the perception interface. The xenobiotic metabolizing enzymes (XMEs) present in the peri-receptor space may participate to the clearance of molecules thus limiting chemosensory receptors saturation and promoting the termination of the signal. In our PhD thesis, the involvement of these enzymes in the detection of stimuli in mixture was assessed in two animal models allowing to test complementary aspects. In Drosophila melanogaster, a sensory exposure to caffeine causes a reversible alteration of the taste percepti…
Odorant Metabolism Analysis by an Automated Ex Vivo Headspace Gas-Chromatography Method
2015
International audience; In the olfactory epithelium (OE), odorant metabolizing enzymes have the dual function of volatile component detoxification and active clearance of odorants from the perireceptor environment to respectively maintain the integrity of the tissues and the sensitivity of the detection. Although emphasized by recent studies, this enzymatic mechanism is poorly documented in mammals. Thus, olfactory metabolism has been characterized mainly in vitro and for a limited number of odorants. The automated ex vivo headspace gas-chromatography method that was developed here was validated to account for odorant olfactory metabolism. This method easily permits the measurement of the f…
Odorant metabolizing enzymes in the peripheral olfactory process
2016
Odorant metabolizing enzymes in the peripheral olfactory process
New insights in vertebrate >
2016
International audience
Inhibition of the mammary pheromone catabolism by a second odorant present in the same mixture
2014
National audience
Odorant-odorant metabolic competitions: ex vivo inhibition of the mammary pheromone catabolism
2016
International audience
New insights in vertebrate 'biotransfolfaction'
2016
International audience