0000000000346015
AUTHOR
Cancila
La Sicilia nella monarchia di Filippo IV. Politica e società
Politics and society in the Catholic monarchy of Philip IV: Kingdom of Sicily
Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
AbstractNeutrophil extracellular traps (NET) are web-like chromatin structures composed by dsDNA and histones, decorated with anti-microbial proteins. Their interaction with dendritic cells (DC) allows DC activation and maturation toward presentation of NET-associated antigens. Differently from other types of cell death that imply protein denaturation, NETosis preserves the proteins localized onto the DNA threads for proper enzymatic activity and conformational status, including immunogenic epitopes. Besides neutrophils, leukemic cells can release extracellular traps displaying leukemia-associated antigens, prototypically mutant nucleophosmin (NPMc+) that upon mutation translocates from nuc…
Poteri e riforme nella Sicilia di Carlo di Borbone
The arrival of Charles of Bourbon in Sicily caused great hopes within the “Spanish party” but, at the same time, the fear that the new dynastic unity with Naples would result in the loss of political and military independence of the island. The Giunta per gli Affari di Sicilia (Council for the Affairs of Sicily) should have been a guarantor institution in the Neapolitan perspective, but in reality the Parliament and especially the Deputazione del Regno (Deputation of the kingdom) were the advocates of the Kingdom’s interests. In Sicily the launch of the reforms process was cautious and concentrated on ecclesiastical jurisdiction, without compromising the relationship with the nobles, whose …