0000000000347329
AUTHOR
Jan Szymoniak
Organochromium complexes - labelled aminoglycoside antibiotics derived from kanamycin A and tobramycin. Synthesis, structural characterization and use as metallotracers for immunoassays.
Abstract The synthesis of metallocenic derivatives of aminoglycoside antibiotics, i. e. kanamycin A and tobramycin, is described. The organometallic-labelled compounds have been obtained from the reaction between the polyaminodrugs and organochromium esters of N-hydroxysuccinimide. The reaction proceeded selectively at the 6′-N position, as might be deduced both from the mass and the pH-dependent 13 C-NMR spectra. The procedure could be regarded as generally useful for the metallolabelling of aminoglycoside antibiotics. As an example of application a competitive immunoassay based on the use of these labels is proposed.
Effects of substitutions on cyclopentadienyl rings in complexes with molybdenum-mercury bonds. 95Mo and 199Hg NMR studies
NMR data for 95Mo and 199Hg nuclei have been obtained for new di- and trimetallic complexes Cp′(CO)3MoHgX containing molybdenum-mercury bonds and bulky and/or potentially bifunctional substituted cyclopentadienyl ligands; Cp′=C5HMe2Ph2, C5Me4Bz, C5Bz5, C5H4PPh2 and C5Me4PPh2 (Bz=CH2C6H5; Me =CH3; Ph=C6H5); X=Cp′(CO)3Mo, Cl, Br, 1, SCN. They are discussed within the context of our earlier results reported for analogous complexes with the cyclopentadienyl ligands bearing methyl groups. With the exception of phenyl substituted rings, a rather narrow range of 95Mo chemical shifts is found for the compounds with the same number of different substituents on cyclopentadienyl ligands. An outstandin…