0000000000347502

AUTHOR

Reinhard Brückner

showing 3 related works from this author

Book Review: Reizvolle Moleküle der Organischen Chemie.(Series: Teubner Studienbücher Chemie). By F. Vögtle

1991

ChemistryGeneral MedicineGeneral ChemistryCatalysisAngewandte Chemie International Edition in English
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The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase…

1978

The effects of phenylephrine on the shape of the contraction curve and on the cyclic adenosine 3',5'-monophosphate (c-AMP) content were studied in electrically driven (frequency 0.2 Hz) cat papillary muscles. All experiments were done in the presence of 1 micron propranolol in order to minimize interference from beta-adrenoceptors. 1. Phenylephrine increased the force of contraction in a concentration-dependent manner. Maximal effects (about 200% of control) occurred at 30 micron phenylephrine. 2. The positive inotropic effect (PIE) of phenylephrine was antagonized by phentolamine. Phentolamine, 5 micron, produced a parallel shift of the concentration-response curve for the PIE of phenyleph…

Inotropemedicine.medical_specialtyContraction (grammar)Time FactorsPharmacology toxicologyAdrenergic beta-AntagonistsPropranololIn Vitro TechniquesPhenylephrineHeart RateInternal medicinemedicineCyclic AMPAnimalsDrug InteractionsPhentolaminePhenylephrinePharmacologyChemistryMyocardiumGeneral MedicineAdenosineMyocardial ContractionPropranololC++ AMPStimulation ChemicalEndocrinologyCatsTime to peakmedicine.drugNaunyn-Schmiedeberg's archives of pharmacology
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Reizvolle Moleküle der Organischen Chemie. (Reihe: Teubner Studienbücher Chemie). Von F.Vögtle. Teubner, Stuttgart 1989. 402 S., Paperback DM 39.80 —…

1990

General MedicineAngewandte Chemie
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