0000000000348024

AUTHOR

Pengyu Zhang

showing 2 related works from this author

The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets

2020

Distinct membrane receptors activate platelets by Src-family-kinase (SFK)-, immunoreceptor-tyrosine-based-activation-motif (ITAM)-dependent stimulation of spleen tyrosine kinase (Syk). Recently, we reported that platelet activation via glycoprotein (GP) VI or GPIb&alpha

Blood Platelets0301 basic medicinePlatelet AggregationPhosphataseSykchemical and pharmacologic phenomena030204 cardiovascular system & hematologyenvironment and public healthspleen tyrosine kinase (Syk)ArticleCatalysisInorganic ChemistryDephosphorylationglycoprotein VIglycoprotein Ibα03 medical and health sciences0302 clinical medicineHumansSyk KinaseProtein Phosphatase 2Platelet activationPhosphorylationPhysical and Theoretical ChemistryMolecular BiologySpectroscopyProtein kinase CChemistryKinaseprotein phosphatase 2AOrganic Chemistryhemic and immune systemsGeneral MedicineProtein phosphatase 2Protein-Tyrosine KinasesPlatelet Activation3. Good healthComputer Science ApplicationsCell biologyenzymes and coenzymes (carbohydrates)030104 developmental biologyplateletsPhosphorylationbiological phenomena cell phenomena and immunitySignal TransductionInternational Journal of Molecular Sciences
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Molecular Proteomics and Signalling of Human Platelets in Health and Disease

2021

Platelets are small anucleate blood cells that play vital roles in haemostasis and thrombosis, besides other physiological and pathophysiological processes. These roles are tightly regulated by a complex network of signalling pathways. Mass spectrometry-based proteomic techniques are contributing not only to the identification and quantification of new platelet proteins, but also reveal post-translational modifications of these molecules, such as acetylation, glycosylation and phosphorylation. Moreover, target proteomic analysis of platelets can provide molecular biomarkers for genetic aberrations with established or non-established links to platelet dysfunctions. In this report, we review …

Blood PlateletsProteomicsADPProteomeQH301-705.5receptorsProstacyclinReviewPROTEIN-COMPOSITIONProteomicsCatalysisInorganic ChemistryThromboxane A2chemistry.chemical_compoundThrombinREVEALSGPVImedicineHumansSYKPlateletPlatelet activationPhysical and Theoretical ChemistrysignallingBiology (General)Molecular BiologyQD1-999SpectroscopyNITRIC-OXIDEChemistryOrganic ChemistryACTIVATED PLATELETSPATHWAYSGLOBAL PROTEOMEGeneral MedicinePlatelet ActivationproteinsComputer Science ApplicationsCell biologyChemistrypost-translational modificationProteomeplateletsBlood Platelet DisordersGPVIProtein Processing Post-TranslationalSignal Transductionmedicine.drugInternational Journal of Molecular Sciences
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