0000000000350132

AUTHOR

Saaresranta Tarja

0000-0001-9328-963x

showing 12 related works from this author

Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study

2014

Abstract: Obstructive sleep apnoea (OSA) is associated with increased risk of dysglycaemia but the intimate link of these conditions with obesity makes discerning an independent relationship between them challenging. Glycosylated haemoglobin (HbA1c) levels predict adverse cardiovascular outcomes in nondiabetics but there is a lack of population-level data exploring the relationship of HbA1c with OSA. A cross-sectional analysis of 5294 participants in the multinational European Sleep Apnoea Cohort (European Sleep Apnoea Database) study was performed, assessing the relationship of OSA severity with HbA1c levels in nondiabetic subjects, with adjustment for confounding factors. HbA1c levels cor…

AdultBlood GlucoseMalePulmonary and Respiratory Medicinemedicine.medical_specialtyAdolescentCross-sectional studyPolysomnographyintermittent hypoxia insulin resistance diabetes obesityBlood PressurePolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratoriota3111Young Adultstomatognathic systemInternal medicineDiabetes MellitusmedicineHumansProspective StudiesSleep studyHypoxiaAgedAged 80 and overGlycated HemoglobinSleep Apnea ObstructiveAnthropometrymedicine.diagnostic_testbusiness.industryConfoundingSleep apneaOdds ratioMiddle Agedmedicine.diseasenervous system diseasesrespiratory tract diseasesEuropeCross-Sectional StudiesTreatment OutcomeQuartileCardiovascular DiseasesHyperglycemiaMultivariate AnalysisCohortPhysical therapyFemaleHuman medicinebusinessEuropean Respiratory Journal
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Driving habits and risk factors for traffic accidents among sleep apnea patients - a European multi-centre cohort study

2014

Obstructive sleep apnea is associated with increased motor vehicle accident risk, and improved detection of patients at risk is of importance. The present study addresses potential risk factors in the European Sleep Apnea Database and includes patients with suspected obstructive sleep apnea [n = 8476, age 51.5 (12.5) years, body mass index 31.0 (6.6) kg m(-2) , 82.4% driver's licence holders]. Driving distance (km year(-1) ), driver's licence type, sleep apnea severity, sleepiness and comorbidities were assessed. Previously validated risk factors for accident history: Epworth Sleepiness Scale ≥16; habitual sleep time ≤5 h; use of hypnotics; and driving ≥15 000 km year(-1) were analysed acro…

AdultMaleAutomobile DrivingPediatricsmedicine.medical_specialtyAdolescentDatabases FactualCognitive NeurosciencePoison controlSettore MED/10 - Malattie Dell'Apparato RespiratorioCohort StudiesYoung AdultBehavioral NeuroscienceRisk FactorsPrevalencedriving exposure hypersomnia motor vehicle crash registry sleepy driving traffic riskHumansMedicineAttentionRisk factorAgedAged 80 and overSleep Apnea Obstructivebusiness.industryEpworth Sleepiness ScaleAccidents TrafficSleep apneaApneaGeneral MedicineMiddle Agedmedicine.diseaseObesityEuropeObstructive sleep apneaFemaleMedical emergencymedicine.symptomSleepbusinessCohort studyJournal of Sleep Research
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Management of obstructive sleep apnea in Europe.

2011

Objectives: In Europe, the services provided for the investigation and management of obstructive sleep apnoea (OSA) varies from country to country. The aim of this questionnaire-based study was to investigate the current status of diagnostic pathways and therapeutic approaches applied in the treatment of OSA in Europe, qualification requirements of physicians involved in diagnosis and treatment of OSA, and reimbursement of these services. Methods: Two questionnaires were sent to 39 physicians in 22 countries in Europe. In order to standardize the responses, the questionnaire was accompanied by an example. Results: Sleep centers from 21 countries (38 physicians) participated. A broad consist…

medicine.medical_specialtyNeurologyCertificationInternationalityReferralmedicine.medical_treatmentPolysomnographyPolysomnographySettore MED/10 - Malattie Dell'Apparato RespiratorioSurveys and QuestionnairesPositive airway pressuremedicineHumansContinuous positive airway pressureIntensive care medicineReimbursementSleep Apnea ObstructivePublic health services sleep apnea sleep disordered breathing OSA management OSA therapy OSA reibursement OSA treatmentmedicine.diagnostic_testContinuous Positive Airway Pressurebusiness.industrySleep apneaProfessional PracticeMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREGeneral Medicinemedicine.diseaserespiratory tract diseasesObstructive sleep apneaEuropeHealth Care SurveysPublic health servicesSleep apnea Sleep disordered breathing OSA management OSA therapyOSA reimbursement OSA treatmentMedicineHuman medicinebusinessSleep medicine
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Position paper on the management of patients with obstructive sleep apnea and hypertension: joint recommendations by the European Society of Hyperten…

2012

This article is aimed at addressing the current state of the art in epidemiology, pathophysiology, diagnostic procedures and treatment options for appropriate management of obstructive sleep apnea (OSA) in cardiovascular (particularly hypertensive) patients, as well as for the management of cardiovascular diseases (particularly arterial hypertension) in OSA patients. The present document is the result of the work done by a panel of experts participating in the European Union COST (COoperation in Scientific and Technological research) ACTION B26 on OSA, with the endorsement of the European Respiratory Society (ERS) and the European Society of Hypertension (ESH). These recommendations are par…

Societies Scientificmedicine.medical_specialtyPhysiologyArterial hypertension continuous positive airway pressure treatment guidelines hypertension treatment obstructive sleep apnoeaComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioCheyne–Stokes respirationEpidemiologyarterial hypertension continuous positive airway pressure treatment guidelines hypertension treatment obstructive sleep apneaInternal MedicinemedicineHumansmedia_common.cataloged_instanceEuropean unionIntensive care medicinemedia_commonSleep Apnea Obstructivebusiness.industrySleep apneaMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareComorbidityEuropeSurvival RateObstructive sleep apneaBlood pressureHypertensionPractice Guidelines as TopicPosition papermedicine.symptomCardiology and Cardiovascular Medicinebusiness
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Positive airway pressure (PAP) treatment reduces glycated hemoglobin (HbA1c) levels in obstructive sleep apnea patients with concomitant weight loss …

2021

Abstract: Patients with obstructive sleep apnea (OSA) are at increased risk of developing metabolic disease such as diabetes. The effects of positive airway pressure on glycemic control are contradictory. We therefore evaluated the change in glycated hemoglobin (HbA1c) in a large cohort of OSA patients after long-term treatment with positive airway pressure. HbA1c levels were assessed in a subsample of the European Sleep Apnea Database [n=1608] at baseline and at long-term follow up with positive airway pressure therapy (mean 378.9 +/- 423.0 days). In a regression analysis, treatment response was controlled for important confounders. Overall, HbA1c decreased from 5.98 +/- 1.01% to 5.93 +/- …

medicine.medical_specialtyHbA1cCognitive Neuroscience03 medical and health sciencesBehavioral Neurosciencechemistry.chemical_compound0302 clinical medicinepositive airway pressure therapyWeight lossDiabetes mellitusInternal medicinePositive airway pressureWeight LossmedicinePrevalenceHumansGlycemicGlycated HemoglobinSleep Apnea ObstructiveContinuous Positive Airway Pressurebusiness.industrySleep apneaGeneral Medicinemedicine.diseasesleep apnearespiratory tract diseasesObesity MorbidObstructive sleep apnea030228 respiratory systemchemistryConcomitantCardiologyCpapGlycated hemoglobinHuman medicinemedicine.symptombusiness030217 neurology & neurosurgeryJournal of sleep research
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Impact of temperature on obstructive sleep apnoea in three different climate zones of Europe: Data from the European Sleep Apnoea Database (ESADA)

2021

Recent studies indicate that ambient temperature may modulate obstructive sleep apnoea (OSA) severity. However, study results are contradictory warranting more investigation in this field. We analysed 19,293 patients of the European Sleep Apnoea Database (ESADA) cohort with restriction to the three predominant climate zones according to the Koppen-Geiger climate classification: Cfb (warm temperature, fully humid, warm summer), Csa (warm temperature, summer dry, hot summer), and Dfb (snow, fully humid, warm summer). Average outside temperature values were obtained and several hierarchical regression analyses were performed to investigate the impact of temperature on the apnea-hypopnea index …

Cognitive NeuroscienceSettore MED/10 - Malattie Dell'Apparato RespiratorioEnvironmentcomputer.software_genreBody Mass IndexCohort Studies03 medical and health sciencesBehavioral NeuroscienceSleep Apnea SyndromeSleep Apnea Syndromes0302 clinical medicineEnvironmental temperaturestomatognathic systemHumansMedicineOxygen saturation (medicine)Climate zonesSleep Apnea ObstructiveOxygen desaturationDatabasebusiness.industryTemperatureSleep Apnea Obstructive.General MedicineSleep in non-human animalsSleep-related breathing disordersnervous system diseasesrespiratory tract diseasesClinical neurologysleep&#8208030228 respiratory systemClimate zonerelated breathing disorderssleep-related breathing disorderHuman medicineCohort StudiebusinessBody mass indexcomputer030217 neurology & neurosurgeryHumanJournal of Sleep Research
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Clinical phenotypes and comorbidity in European sleep apnoea patients

2016

PubMed ID: 27701416

MalePulmonologyPhysiologyApneamedicine.medical_treatmentlcsh:MedicineComorbidityPolysomnographyCardiovascular MedicineMedicine (all); Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)THERAPYBody Mass Index0302 clinical medicineRisk FactorsPositive airway pressureMedicine and Health SciencesInsomniaMedicineProspective StudiesContinuous positive airway pressurelcsh:ScienceProspective cohort studyClinical NeurophysiologyAged 80 and overHypersomniaMultidisciplinarymedicine.diagnostic_testMedicine (all)Sleep apneaMiddle AgedDEPRESSIONPREVALENCEComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMSPhenotypeNeurologyPhysiological ParametersCardiovascular DiseasesCARDIOVASCULAR-DISEASEFemaleInformationSystems_MISCELLANEOUSmedicine.symptomEngineering sciences. TechnologyHypopneaINSOMNIA SYMPTOMSResearch ArticleAdultmedicine.medical_specialtyInsomniaSleep ApneaAdolescentPOSITIVE AIRWAY PRESSUREPolysomnographySettore MED/10 - Malattie Dell'Apparato RespiratorioWhite PeopleYoung Adult03 medical and health sciencesSleep Apnea SyndromesDAYTIMEstomatognathic systemComorbiditatDiagnostic MedicineInternal medicinemental disordersHumansCOMMONAgedHYPOPNEABiochemistry Genetics and Molecular Biology (all)HYPERTENSIONbusiness.industrylcsh:RBody WeightComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKSBiology and Life Sciencesta3121medicine.diseaseComorbidityDyssomniasrespiratory tract diseasesnervous system diseasesComputingMethodologies_PATTERNRECOGNITIONAgricultural and Biological Sciences (all)030228 respiratory systemPhysical therapylcsh:QSleep DisordersPhysiological ProcessesSleepbusiness030217 neurology & neurosurgeryFollow-Up Studies
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Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

2018

WOS: 000482433800011

AdultMalemedicine.medical_specialtyInsomniaNeurologyComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioNocturnalHypoxemiaHypoxemia03 medical and health sciences0302 clinical medicineRisk FactorsSleep Initiation and Maintenance DisordersInternal medicinemental disordersPrevalenceInsomniaHumansMedicineHypoxiaSleep Apnea Obstructivebusiness.industrySleep Breathing Physiology and Disorders • Original ArticleSleep apneaSleep apneaMiddle AgedCardiovascular disease ; Comorbidity ; Hypoxemia ; Insomnia ; Phenotype ; Sleep apnea.Hypoxia (medical)Cardiovascular diseasemedicine.diseaseComorbidityCircadian Rhythmnervous system diseasesEuropePhenotype030228 respiratory systemOtorhinolaryngologyCardiovascular DiseasesCohortFemaleHuman medicineNeurology (clinical)medicine.symptombusiness030217 neurology & neurosurgerySleep and Breathing
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Comment to the Editorial by KS Park and EW Kang “Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstruct…

2019

We thank doctors Park and Kang for their editorial that well summarized our article. Our common belief is that one of the possible consequences of untreated obstructive sleep apnea (OSA) is an accelerated deterioration of kidney function, and that more knowledge would be necessary on the possible protective effects of OSA treatments. To our knowledge, so far the only OSA therapy whose effects on renal function have been tested is continuous positive airway pressure (CPAP), and most , although not all studies, have demonstrated its benefits. Our own study, while confirming benefits of fixed CPAP, has demonstrated little effect of auto-adjusting CPAP (APAP). This finding may be of relevance a…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyLetterestimated glomerular filtration ratekidney diseaseRenal functionPolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratoriosleep disordered breathingpolysomnographyrenal protectionPositive airway pressureMedicineIn patienthumansleepIntensive care medicinekidney functionLetter to the EditorPositive end-expiratory pressureKidneymedicine.diagnostic_testbusiness.industryobstructive sleep apnea ; kidney protection ; fixed positive airway pressuremedicine.diseaseoxygen saturationrespiratory tract diseasesObstructive sleep apneaNot availablemedicine.anatomical_structureEditorialpositive end expiratory pressureHuman medicinebusinesschronic obstructive lung diseaseKidney disease
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Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA

2018

Abstract: BACKGROUND: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. METHODS: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 14…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyUrologyRenal functionSettore MED/10 - Malattie Dell'Apparato RespiratorioEgfr declineCritical Care and Intensive Care MedicineOSA03 medical and health sciences0302 clinical medicinePositive airway pressuremedicineautomatic CPAPIn patientKidneyglomerular filtration ratetherapybusiness.industrySleep apneafixed CPAPta3121medicine.diseaserespiratory tract diseasesLarge samplemedicine.anatomical_structure030228 respiratory systemCohortHuman medicinebusinessCardiology and Cardiovascular Medicine030217 neurology & neurosurgery
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Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea…

2021

Excessive daytime sleepiness (EDS) is a symptom of obstructive sleep apnea (OSA) that resolves under treatment with continuous positive airway pressure (CPAP). In some patients, sleepiness persists despite CPAP treatment. We retrospectively analyzed data on subjective residual EDS, assessed as an Epworth Sleepiness Scale score (ESS) >10, in patients from the European Sleep Apnea Database (n = 4,853, mean age +/- SD 54.8 +/- 11.8 years, 26.1% females), at baseline and at the first visit (median follow-up: 5 months, interquartile range 3-13). An ESS > 10 occurred in 56% of patients at baseline and in 28.2% of patients at follow-up. Residual EDS was analyzed in 2,190 patients (age: 55.1 +/- 12…

sleep latencyResidual Sleepinessmedicine.medical_treatment[SDV]Life Sciences [q-bio]Excessive daytime sleepinessSettore MED/10 - Malattie Dell'Apparato Respiratoriocomputer.software_genreCpap adherence03 medical and health sciences0302 clinical medicineInterquartile rangeCpap Usemedicinefollow-upContinuous positive airway pressureObesityRC346-429ComputingMilieux_MISCELLANEOUSresidual sleepnessOriginal ResearchWake-Active NeuronsDatabasebusiness.industryresidual sleepineEpworth Sleepiness ScaleSleep apneaEpworth sleepness ScaleEpworth Sleepiness Scalemedicine.diseaseCPAP adherenceImportant Differencenervous system diseasesrespiratory tract diseasesScaleObstructive sleep apneaLifestyle factors030228 respiratory systemNeurologysleep durationHuman medicineNeurology. Diseases of the nervous systemNeurology (clinical)medicine.symptombusinesscomputer030217 neurology & neurosurgery
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Diabetes Mellitus Prevalence and Control in Sleep-Disordered Breathing

2014

BACKGROUND OSA is associated with an increased risk of cardiovascular morbidity. A driver of this is metabolic dysfunction and in particular type 2 diabetes mellitus (T2DM). Prior studies identifying a link between OSA and T2DM have excluded subjects with undiagnosed T2DM, and there is a lack of population-level data on the interaction between OSA and glycemic control among patients with diabetes. We assessed the relationship between OSA severity and T2DM prevalence and control in a large multinational population. METHODS We performed a cross-sectional analysis of 6,616 participants in the European Sleep Apnea Cohort (ESADA) study, using multivariate regression analysis to assess T2DM preva…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyendocrine system diseasesmedicine.diagnostic_testCross-sectional studybusiness.industrynutritional and metabolic diseasesSleep apneaType 2 Diabetes MellitusPolysomnographyCritical Care and Intensive Care Medicinemedicine.diseaseMedication prescriptionrespiratory tract diseasesApnea–hypopnea indexInternal medicineCohortSeverity of illnessPhysical therapymedicineCardiology and Cardiovascular MedicinebusinessChest
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