0000000000350752

AUTHOR

Alessandra Mazzola

showing 5 related works from this author

Recurrence of hepatocellular carcinoma after liver transplantation: an update.

2015

Liver transplantation is the only curative alternative for selected patients with hepatocellular carcinoma (HCC) who are not eligible for resection and/or with decompensated cirrhosis. According to Milan criteria the 5-year survival rate is 70–85%, with a recurrence-free survival of 75%. However, HCC recurrence rate after liver transplantation remains a significant problem in the clinical practice. The prognosis in patients with HCC recurrence is poor. The treatment of choice for HCC recurrence is surgery, but it seems that a systemic treatment based on combination of an mTOR inhibitor with sorafenib can be used. Data on safety and efficacy are limited, clinical monitoring is necessary. Th…

SorafenibOncologyCancer Researchmedicine.medical_specialtyrecurrenceCarcinoma Hepatocellularmedicine.medical_treatmentliving donorLiver transplantationMilan criteriaGastroenterologyLeukocyte CountRisk FactorsInternal medicinemedicineBiomarkers TumorCombined Modality TherapyHumansalpha-FetoproteinPerioperative PeriodSurvival rateimmunosuppressionbusiness.industryRisk FactorLiver NeoplasmsImmunosuppressionGeneral MedicinePerioperativehepatocellular carcinomamedicine.diseaseCombined Modality Therapydigestive system diseasesLiver TransplantationTumor BurdenOncologyLiver NeoplasmHepatocellular carcinomaalpha-FetoproteinsNeoplasm Recurrence Localbusinessmedicine.drugHumanFuture oncology (London, England)
researchProduct

Acute liver failure and HELLP syndrome: A clinical case and literature review.

2021

Summary Background HELLP syndrome is a pregnancy-related liver disease associated with increased maternal and foetal mortality. In rare cases, it can lead to the development of a subcapsular hepatic haematoma as well as its rupture. This rupture is life-threatening if not urgently treated. Method We describe a clinical case of HELLP syndrome involving a ruptured subcapsular liver haematoma and contextualise this with a literature overview. Clinical case A 39-year-old woman of 40 weeks’ gestation presented to her local Emergency Department with symptoms and serology classically associated with HELLP syndrome. However, she clinically deteriorated and developed a ruptured subcapsular haematoma…

Adultmedicine.medical_specialtyHELLP SyndromeHELLP syndromemedicine.medical_treatmentLiver transplantation03 medical and health sciencesLiver disease0302 clinical medicinePregnancymedicineHumansHematomaHepatologybusiness.industryCesarean SectionLiver DiseasesGastroenterologyLiver failureEmergency Caesarean SectionEmergency departmentLiver Failure Acutemedicine.diseaseSurgery030220 oncology & carcinogenesisGestation030211 gastroenterology & hepatologyFemaleClinical casebusinessClinics and research in hepatology and gastroenterology
researchProduct

Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

2018

IF 3.756; International audience; De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomédecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was app…

AdultMaleAlcoholic liver diseasemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentPopulation[SDV.CAN]Life Sciences [q-bio]/Cancer030230 surgeryLiver transplantationGastroenterologyRisk AssessmentLiver transplantation (LT)End Stage Liver Disease03 medical and health sciences0302 clinical medicinePostoperative ComplicationsRisk FactorsInternal medicineNeoplasmsmedicineHumanseducationLiver Diseases AlcoholicTransplantationeducation.field_of_studyHepatologybusiness.industryIncidence (epidemiology)IncidenceAbsolute risk reductionMiddle Agedmedicine.diseaseConfidence interval3. Good healthLiver TransplantationStandardized mortality ratioTreatment Outcome030211 gastroenterology & hepatologySurgeryFemaleFranceRisk assessmentbusinessFollow-Up Studies
researchProduct

Biliary complications after liver transplantation: current perspectives and future strategies

2021

Importance: Liver transplantation (LT) is a life-saving therapy for patients with end-stage liver disease and with acute liver failure, and it is associated with excellent outcomes and survival rates at 1 and 5 years. The incidence of biliary complications (BCs) after LT is reported to range from 5% to 20%, most of them occurring in the first three months, although they can occur also several years after transplantation.Objective: The aim of this review is to summarize the available evidences on pathophysiology, risk factors, diagnosis and therapeutic management of BCs after LT.Evidence Review: a literature review was performed of papers on this topic focusing on risk factors, classificatio…

medicine.medical_specialtyEndoscopic retrograde cholangiopancreatographyPercutaneousmedicine.diagnostic_testBile ductbusiness.industryLiver transplantation (LT) biliary tract diseases cholangiography cholangiopancreatography endoscopic retrograde reviewmedicine.medical_treatment030230 surgeryLiver transplantationmedicine.diseaseSurgeryTransplantation03 medical and health sciencesLiver disease0302 clinical medicinemedicine.anatomical_structureCholangiographymedicineEtiology030211 gastroenterology & hepatologybusinessHepatobiliary Surgery and Nutrition
researchProduct

Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.

2012

BACKGROUND: Genotype 1 (G1) chronic hepatitis C (CHC) patients achieving a rapid virological response (RVR) on pegylated interferon (PEG-IFN) plus ribavirin have a high chance of sustained virological response (SVR), influenced by IL28B status, viral load, fibrosis and insulin resistance. We assessed whether 25-hydroxyvitamin D (25[OH]D) serum levels are linked to RVR and can be used together with IL28B to construct a pretreatment model to predict RVR. METHODS: A total of 117 consecutive patients with G1 CHC were evaluated by biopsy and anthropometric and metabolic measurements. 25(OH)D serum levels were measured by HPLC. IL28B rs12979860 and rs8099917 polymorphisms were also evaluated. All…

Vitamin DIL28B chronic hepatitis C
researchProduct