Author: Sabīne Kaštaļjana

0000000000351195

AUTHOR

Sabīne Kaštaļjana

Tetrazīna fragmentu saturošu linkeru sintēze proteīnu modificēšanai

Maģistra darbā ir veikta jaunu, alifātisku un PEG fragmentus saturošu, tetrazīna linkeru sintēze proteīnu biokonjugācijai. Darba ietvaros iegūti un izolēti 3 linkeri, kas paredzēti neselektīvai Lys aminoskābju atlikumu modificēšanai, un arī iegūti vēl 3 linkeri, kas paredzēti reģiospecifiskai proteīna N-gala modificēšanai. Darba ietvaros arī izolēts viens linkeris, kas paredzēts His modificēšanai. Visi sintezētie linkeri tika testēti modificējot Borrelia Burgdorferi MlpC lipoproteīnu, kā arī veikta paraugu MALDI-TOF MS analīze, kurā no septiņiem linkeriem, seši ir uzrādījuši konjugāta veidošanos ar MlpC.

research product

Jaunu linkeru sintēze proteīnu biokonjugācijai

Bakalaura darba ietvaros tika izstrādāta jaunu linkeru sintēze proteīnu biokonjugācijai to potenciālai izmantošanai VVD-NGF biokonjugātu sintēzē.

research product

PEPhysical Sciences and Engineering
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