Tetrazīna fragmentu saturošu linkeru sintēze proteīnu modificēšanai

6533b7dafe1ef96bd126dbd6

RESEARCH PRODUCT

Tetrazīna fragmentu saturošu linkeru sintēze proteīnu modificēšanai

subject

LINKERI BIOKONJUGĀCIJA TETRAZĪNI PROTEĪNS MLPC Ķīmija

description

Maģistra darbā ir veikta jaunu, alifātisku un PEG fragmentus saturošu, tetrazīna linkeru sintēze proteīnu biokonjugācijai. Darba ietvaros iegūti un izolēti 3 linkeri, kas paredzēti neselektīvai Lys aminoskābju atlikumu modificēšanai, un arī iegūti vēl 3 linkeri, kas paredzēti reģiospecifiskai proteīna N-gala modificēšanai. Darba ietvaros arī izolēts viens linkeris, kas paredzēts His modificēšanai. Visi sintezētie linkeri tika testēti modificējot Borrelia Burgdorferi MlpC lipoproteīnu, kā arī veikta paraugu MALDI-TOF MS analīze, kurā no septiņiem linkeriem, seši ir uzrādījuši konjugāta veidošanos ar MlpC.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59465

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