0000000000352128

AUTHOR

Catherine Lavaud

showing 2 related works from this author

30-Norfriedelane triterpenes from the stem bark ofCaloncoba glauca

1992

Abstract The stem bark of Caloncoba glauca has yielded three friedelane triterpenes of which two are characterized by the loss of C-30 and the presence of a C-27, C-15 lactone. They were identified, with considerable use of long-range C H coupling studies, as the known compound trichadonic acid (3-oxofriedelan-27-oic acid) and two new 30-norfriedelane derivatives, 3,27-dioxo-30-norfriedelan-20(29)-en-27,15α-lactone (caloncobalactone) and 3,27-dioxo-21β-hydroxy-30-norfriedelan-20(29)-en-17,15α-lactone (21β-hydroxycaloncoba lactone).

chemistry.chemical_classificationStem barkbiologyChemistryStereochemistryPlant ScienceGeneral MedicineHorticulturebiology.organism_classificationBiochemistryTerpeneFlacourtiaceaeTriterpenevisual_artvisual_art.visual_art_mediumOrganic chemistryBarkMolecular BiologyLactonePhytochemistry
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New method for the determination of the absolute stereochemistry in antitumoral annonaceous acetogenins

1998

Abstract The absolute configurations at the carbinol centers in several acetogenins were determined through p-bromophenylurethane derivatives and subsequent Mosher ester methodology. This method has been applied on α,α′-dihydroxylated adjacent bis-THF acetogenins with a threo/cis/threo/cis/erythro relative configuration membrarollin (1), a new acetogenin isolated from Rollinia membranacea seeds, rollimembrin (2), membranacin (3) and rolliniastatin-1 (4), and a threo/trans/threo/translerythro relative configuration motrilin (5), squamocin (6), and desacetyluvaricin (7). 1 was found to be the most potent inhibitor of the mammalian mitochondrial complex I.

Rollinia membranaceaChemistryStereochemistryOrganic ChemistryMembranacinDiastereomerRollimembrinBiochemistrychemistry.chemical_compoundDrug DiscoveryAcetogeninAnnonaceous AcetogeninsDesacetyluvaricinMitochondrial Complex ITetrahedron
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