0000000000353015

AUTHOR

Enrico Rampazzo

0000-0003-2290-859x

showing 3 related works from this author

Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies

2015

Sara Capolla,1 Chiara Garrovo,2 Sonia Zorzet,1 Andrea Lorenzon,3 Enrico Rampazzo,4 Ruben Spretz,5 Gabriele Pozzato,6 Luis Núñez,7 Claudio Tripodo,8 Paolo Macor,1,9 Stefania Biffi2 1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 3Animal Care Unit, Cluster in Biomedicine (CBM scrl), Trieste, Italy; 4Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy; 5LNK Chemsolutions LLC, Lincoln, NE, USA; 6Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; 7Bio-Target, Inc., University of C…

Medicine (General)Active targeting; Optical imaging; Tumor accumulation; Animals; Antigens CD20; Cell Line Tumor; Humans; Leukemia B-Cell; Mice; Molecular Imaging; Nanoparticles; Polymers; Drug Delivery Systems; Bioengineering; Biophysics; Biomaterials; Drug Discovery3003 Pharmaceutical Science; Organic ChemistryTumor accumulationPolymersPharmaceutical SciencePharmacologyOptical imagingMiceDrug Delivery SystemsNanoparticleInternational Journal of NanomedicineDrug DiscoveryPolymerOriginal ResearchActive targeting; Optical imaging; Tumor accumulation; Animals; Antigens CD20; Cell Line Tumor; Humans; Leukemia B-Cell; Mice; Molecular Imaging; Nanoparticles; Polymers; Drug Delivery Systems; Biophysics; Bioengineering; Biomaterials; Organic Chemistry; Drug Discovery3003 Pharmaceutical ScienceTumorLeukemiaActive targetingtumor accumulationGeneral MedicineMolecular ImagingDrug deliverySystemic administrationPreclinical imagingHumanactive targetingMaterials scienceBiophysicsBioengineeringCell LineBiomaterialsoptical imagingR5-920In vivoCell Line TumormedicineLeukemia B-CellDistribution (pharmacology)AnimalsHumansCD20AntigensAnimalDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistryB-CellCancermedicine.diseaseAntigens CD20BiomaterialTargeted drug deliveryBiophysicNanoparticlesMolecular imagingDrug Delivery System
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OP0023 Targeted Polymeric Nanoparticles as Diagnostic and Therapeutic Tool for Rheumatoid Arthritis

2016

Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting joints due to the persistent synovial tissue inflammation. RA treatment has dramatically evolved in the last 20 years due to the production of biological Disease Modifying Antirheumatic Drugs (bDMARDs). However, side effects and the high costs of biological drugs are holding back their widespread usage. Moreover, some patients fail to respond to bDMARDs, for all of these reasons, DMARDs remains the main desired strategy for the treatment of RA, and Methotrexate (MTX) is still the “anchor” drug to treat RA. A successful treatment depends also on the early diagnosis, treating patients as soon as possible …

Drugrheumatoid arthritisInflammatory arthritismedia_common.quotation_subjectImmunologyArthritisInflammationPharmacologyGeneral Biochemistry Genetics and Molecular BiologymethotrexateRheumatologyIn vivomedicineImmunology and Allergyrheumatoid arthritis; nanoparticles; collagen induced arthritis; methotrexatemedia_commonbusiness.industrynanoparticleTherapeutic effectrheumatoid arthritimedicine.diseasecollagen induced arthritiscollagen induced arthritiRheumatoid arthritisImmunologyMethotrexatenanoparticlesmedicine.symptombusinessmedicine.drug
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Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis

2019

Abstract Despite the advances in the treatment of rheumatoid arthritis (RA) achieved in the last few years, several patients are diagnosed late, do not respond to or have to stop therapy because of inefficacy and/or toxicity, leaving still a huge unmet need. Tissue-specific strategies have the potential to address some of these issues. The aim of the study is the development of a safe nanotechnology approach for tissue-specific delivery of drugs and diagnostic probes. CD34 + endothelial precursors were addressed in inflamed synovium using targeted biodegradable nanoparticles (tBNPs). These nanostructures were made of poly-lactic acid, poly-caprolactone, and PEG and then coated with a synovi…

musculoskeletal diseases0301 basic medicineBiodistributionCD34; +; cells; Neoangiogenesis; Rheumatoid arthritis; Targeted nanoparticles; Targeted therapymedicine.medical_treatmentTargeted nanoparticlesImmunologyArthritisInflammation+Targeted therapyTargeted therapy03 medical and health sciences0302 clinical medicinemedicineImmunology and AllergyProgenitor cellRheumatoid arthritisRheumatoid arthritiTargeted nanoparticleNeoangiogenesis030203 arthritis & rheumatologybusiness.industrycellmedicine.diseaseNeoangiogenesi030104 developmental biologyRheumatoid arthritisToxicityCancer researchcellsMethotrexateCD34medicine.symptombusinessmedicine.drug
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