0000000000353314

AUTHOR

Göran Pershagen

showing 3 related works from this author

Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe

2018

Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. Methods: Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified …

Pediatricsmedicine.medical_specialtyEpidemiologyNitrogen DioxideEnvironmental pollution010501 environmental sciences01 natural sciencesOdds03 medical and health sciences0302 clinical medicinePregnancyAir PollutionmedicineHumanslongitudinal studies030212 general & internal medicineChildProspective cohort study0105 earth and related environmental scienceschild developmentparticulate matterInhalation ExposurePregnancybusiness.industryattention deficit disorder with hyperactivityOdds ratiomedicine.diseaseChild developmentConfidence intervalprospective studies3. Good healthEuropemeta-analysisnitrogen oxidesChild PreschoolPrenatal Exposure Delayed EffectsMeta-analysisFemaleenvironmental pollutionAttention Deficit Disorder With Hyperactivity ; Child Development ; Environmental Pollution ; Longitudinal Studies ; Meta-analysis ; Nitrogen Oxides ; Particulate Matter ; Prospective Studiesbusiness
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DNA methylation in childhood asthma

2018

Background: DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood asthma. Methods: We did a large-scale epigenome-wide association study (EWAS) within the Mechanisms of the Development of ALLergy (MeDALL) project. We examined epigenome-wide methylation using Illumina Infinium Human Methylation450 BeadChips (450K) in whole blood in 207 children with asthma and 610 controls at age 4–5 years, and 185 children with asthma and 546 controls at age 8 years using a cross-sectional case-control design. After identification of differentially m…

Male0301 basic medicineAllergyCytotoxicT-Lymphocytes[SDV]Life Sciences [q-bio]Respiratory Systemlnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]CHILDRENImmunoglobulin EEpigenesis GeneticChildPOPULATIONeducation.field_of_studybiologyMethylation3. Good healthCpG siteChild PreschoolDNA methylationFemaleBIOS ConsortiumLife Sciences & BiomedicinePulmonary and Respiratory MedicinePopulationPHENOTYPESIMMUNITY03 medical and health sciencesCritical Care MedicineGeneticGeneral & Internal MedicinemedicineHumansCOHORTEpigeneticsIGEEXPOSUREPreschooleducationAsthmaScience & Technologybusiness.industryRHINITISDNADNA Methylationmedicine.diseaseAsthmaEosinophils030104 developmental biology3121 General medicine internal medicine and other clinical medicineImmunologybiology.proteinGENOMEWIDE ASSOCIATIONCpG IslandsbusinessCOLLECTIONT-Lymphocytes CytotoxicEpigenesisGenome-Wide Association StudyThe Lancet. Respiratory Medicine
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Air pollution exposure during pregnancy and childhood autistic traits in four European population-based cohort studies: The ESCAPE Project

2015

Background: Prenatal exposure to air pollutants has been suggested as a possible etiologic factor for the occurrence of autism spectrum disorder. Objectives: We aimed to assess whether prenatal air pollution exposure is associated with childhood autistic traits in the general population. Methods: Ours was a collaborative study of four European population-based birth/child cohorts—CATSS (Sweden), Generation R (the Netherlands), GASPII (Italy), and INMA (Spain). Nitrogen oxides (NO2, NOx) and particulate matter (PM) with diameters of ≤ 2.5 μm (PM2.5), ≤ 10 μm (PM10), and between 2.5 and 10 μm (PMcoarse), and PM2.5 absorbance were estimated for birth addresses by land-use regression models bas…

medicine.medical_specialtyInfants -- Malaltiesnitrogen oxideHealth Toxicology and MutagenesisAir pollution exposureeducation05 Environmental Sciencesair pollutionAir pollutionautismprenatal exposuremedicine.disease_causeToxicologysmokingAire -- Contaminació -- EspanyaEnvironmental healthMedicinePsychiatryPregnancybusiness.industrychildhood diseasePublic Health Environmental and Occupational HealthEuropean population11 Medical And Health Sciencesmedicine.disease3. Good healthPeer reviewAutistic traits13. Climate actionChildren's HealthAutismpregnancybusinessCohort study
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