0000000000353606
AUTHOR
A. Davì
Disease outcomes after DAA-induced SVR: Data from the resist-HCV cohort
Background and aims: Large scale, real life data on the long term course of liver disease after HCV clearance obtained with DAAs are still scanty, and the separate effects on hepatic and non-hepatic causes of death still unclear. Method: We evaluated 4147 patients (mean age: 65.7 ± 11.5 years, 57.6% males) included in the prospective RESIST-HCV cohort who started DAAs treatment in 22 centres between March 2015 and April 2017. All patients were follow after SVR to register liver-related and unrelated outcomes. The primary endpoint was the evaluation of survival since starting DAAs. Cox regression analysis was used to assess the predictors of liver-related and unrelated death. Results: Patien…
Is Transient Elastography Needed for Noninvasive Assessment of High-Risk Varices? The REAL Experience
INTRODUCTION: The Baveno VI consensus guidelines and an expanded algorithm suggest that transient elastography (TE) and platelet (PLT) count can be used to identify patients with cirrhosis who can avoid esophagogastroduodenoscopy (EGD). The primary aims of this study were to assess the ability of a simple algorithm, which uses only laboratory parameters, to predict medium/large esophageal varices (EV) in patients with hepatitis C virus (HCV) and cirrhosis from the Rete Sicilia Selezione Terapia-HCV (RESIST-HCV) cohort and to compare the performance of the algorithm with Baveno VI and Expanded Baveno VI criteria. The secondary aim was to assess the role of TE in ruling out large EV. METHODS:…
Incidence of Hepatocellular Carcinoma in Patients With HCV-Associated Cirrhosis Treated With Direct-Acting Antiviral Agents.
Background & Aims: Studies have produced conflicting results of the incidence of hepatocellular carcinoma (HCC) in patients with hepatitis C virus–associated cirrhosis treated with direct-acting antivirals (DAAs). Data from clinics are needed to accurately assess the occurrence rate of HCC in patients with cirrhosis in the real world. Methods: We collected data from a large prospective study of 2,249 consecutive patients (mean age = 65.4 years, 56.9% male) with hepatitis C virus–associated cirrhosis (90.5% with Child-Pugh class A and 9.5% with Child-Pugh class B) treated with DAAs from March 2015 through July 2016 at 22 academic and community liver centers in Sicily, Italy. HCC occurren…
Valutazione bioagronomica e stabilità produttiva in genotipi di veccia comune (Vicia sativa L.).
La Veccia (Vicia sativa L.) rappresenta per le regioni caldo-aride del bacino del Mediterraneo una specie di notevole interesse sia per la produzione di biomassa utile per l’alimentazione dei ruminanti, sia per la produzione di granella e sia per il posto che occupa all’interno degli avvicendamenti colturali asciutti. In Italia nonostante la produzione di seme certificato è abbastanza diffusa in quasi tutte le regioni del centro-sud, annualmente una quantità significativa di granella per uso zootecnico viene importata da Paesi europei ed extra-europei e poi utilizzata anche come seme non certificato. Per questo motivo si è ritenuto opportuno avviare uno studio del comportamento bio-agronomi…