0000000000355128

AUTHOR

Lorena Delle Donne

showing 3 related works from this author

Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report.

2013

The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activat…

Malemedicine.medical_specialtyAngiogeninBrachial ArteryAngiogenesisHealth Toxicology and MutagenesisClinical BiochemistryNeovascularization PhysiologicCardiovascular disease growth factors/cytokines/inflammatory mediators sports science/exerciseInflammationPilot ProjectsBiochemistryNeovascularizationInternal medicinemedicineAerobic exerciseHumanscardiovascular diseasesProspective StudiesEndothelial dysfunctionAngiogenic ProteinsExerciseAgedHeart Failurebusiness.industryStem CellsEndothelial CellsStroke VolumeStroke volumeMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareExercise TherapyVasodilationTreatment OutcomeHeart failureImmunologyChronic Diseasecardiovascular systemCardiologymedicine.symptombusinessBiomarkerscirculatory and respiratory physiologyBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
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<p>Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD</p>

2019

Background Airway inflammation may drive the progression of chronic obstructive pulmonary disease (COPD) associated with alpha-1 antitrypsin deficiency (AATD), but the relationship between airway microbiota and inflammation has not been investigated. Methods We studied 21 non-treated AATD (AATD-noT) patients, 20 AATD-COPD patients under augmentation therapy (AATD-AT), 20 cigarette smoke-associated COPD patients, 20 control healthy smokers (CS) and 21 non-smokers (CON) with normal lung function. We quantified sputum inflammatory cells and inflammatory markers (IL-27, CCL3, CCL5, CXCL8, LTB4, MPO) by ELISA, total bacterial load (16S) and pathogenic bacteria by qRT-PCR. Results AATD-AT patient…

medicine.medical_specialtyCOPDAlpha 1-antitrypsin deficiencybusiness.industryCCL3InflammationGeneral Medicinemedicine.diseaseGastroenterologyrespiratory tract diseasesDLCOInternal medicinemedicineSputumInterleukin 8medicine.symptombusinessAirwayInternational Journal of Chronic Obstructive Pulmonary Disease
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Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity.

2014

AbstractBackground: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation.Aim: To quantify serum levels of fibrosis regulators in CHF.Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n = 9; II, n = 34; III n = 23), and in 14 controls.Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1.Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.

medicine.medical_specialtyHealth Toxicology and MutagenesisClinical BiochemistryInflammationBiochemistryGastroenterologySeverity of Illness IndexBone morphogenetic protein 1ElectrocardiographyFibrosisInternal medicinemedicineEndothelial dysfunction heart fibrosis inflammationHumanscardiovascular diseasesEndothelial dysfunctionHeart Failurebusiness.industryMembrane ProteinsBone Morphogenetic Protein Receptorsmedicine.diseaseFibulinProcollagen peptidaseHeart failureImmunologyChronic Diseasecardiovascular systemBAMBImedicine.symptombusinesscirculatory and respiratory physiology
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