6533b7dafe1ef96bd126e35b
RESEARCH PRODUCT
Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report.
Alessandro MezzaniAdriano TaddeoSilvia Della BellaLorena Delle DonneDavide ValleseIsabella GnemmiErmanno EleuteriAntonino Di StefanoPantaleo Giannuzzisubject
Malemedicine.medical_specialtyAngiogeninBrachial ArteryAngiogenesisHealth Toxicology and MutagenesisClinical BiochemistryNeovascularization PhysiologicCardiovascular disease growth factors/cytokines/inflammatory mediators sports science/exerciseInflammationPilot ProjectsBiochemistryNeovascularizationInternal medicinemedicineAerobic exerciseHumanscardiovascular diseasesProspective StudiesEndothelial dysfunctionAngiogenic ProteinsExerciseAgedHeart Failurebusiness.industryStem CellsEndothelial CellsStroke VolumeStroke volumeMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareExercise TherapyVasodilationTreatment OutcomeHeart failureImmunologyChronic Diseasecardiovascular systemCardiologymedicine.symptombusinessBiomarkerscirculatory and respiratory physiologydescription
The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-06-27 | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals |