0000000000357667
AUTHOR
Marino R.
Improving reliability of road estimates based on high correlated accidents counts
Approccio teorico-sperimentale per l'analisi delle condizioni opertaive di rotatorie urbane non convenizonali.
I metodi tradizionali di analisi delle intersezioni a rotatoria non consentono una valutazione attendibile delle condizioni operative del traffico in presenza di schemi organizzativi dell’intersezione, nei quali la geometria, unitamente alla molteplicità delle situazioni di traffico ed all’inserimento in contesti vincolati, induce comportamenti di guida anche molto distanti da quelli osservabili in rotatorie convenzionali. Quanto evidenziato interessa, in particolare, gli schemi circolari di intersezione in area urbana, dove risultano particolarmente diffusi e si caratterizzano per requisiti geometrico-funzionali spesso distanti da quelli propri delle rotatorie convenzionali. I vincoli loca…
A new dopamine amino-acid conjugate: preclinical in vitro studies and evaluation of behavioural effects in rats
It is well established that alterations in the functionality of dopaminergic transmission are associated with neurodegenerative diseases such as Parkinson’s Disease. The purpose of this study was to investigate the activity of a new dopamine amino-acid conjugate: L-phenylalanine-β-(3,4-dihydroxyphenyl) etilamide(DA-Phe) in the central nervous system, by assessing its influence on different behavioural parameters in the rat. Preliminarily, we tested the in vitro stability in plasmatic environment following the disappearance of DA-Phen from human plasma and the concurrent appearance of dopamine. Using rat brain homogenate, we also evaluated the level of DA-Phen cleavage by cerebral enzymes an…
Modeling traffic operations and drivers' behavioral parameters at not-conventional roundabouts. A theoretic-experimental approach
The inapplicability of current methods based on gap-acceptance theory for analyzing operational conditions at not-conventional roundabouts (very frequent in urban areas) seriously hampers the performance assessment; in practical applications, this also makes the choice of corrective design measures very uncertain. Starting from this considerations, the present paper shows the conceptual path followed for analyzing traffic operations at multilane-large-diameter not-conventional roundabouts. The research follows a theoretic-experimental approach that intends to put in a fair equilibrium the need both to match field observations and to have a general criterion to determine behavioral parameter…
Addressing the impact of SARS-CoV-2 infection in persons with congenital bleeding disorders: The Italian MECCOVID-19 study
congenital bleeding disorders
Improving reliability of road safety estimates based on high correlated accidents counts
Calibrating a safety performance function (SPF) with many years of accident data creates a temporal correlation that traditional model calibration procedures cannot deal with. It is well known that generalized estimating equations (GEE) models are able to incorporate trends into accident data and thus overcome difficulties in accounting for correlation; the usual application of GEEs to safety analysis uses robust (or sandwich) estimates of regression coefficients under the independence hypothesis for the working correlation matrix. This practice is justified by the robustness of the GEE procedure against misspecification of the response correlation structure. Nevertheless, with this method,…