Optimization Strategies for the Anodic Phenol‐Arene Cross‐Coupling Reaction

Investigations on isomerization and rearrangement of polycyclic arenes under oxidative conditions – Anodic versus reagent-mediated reactions

Abstract Electro-organic conversions at an active molybdenum anode enable the formation of fused arenes. High chemoselectivity was achieved under anodic conditions, and a reagent-induced selectivity was observed by comparison with results of MoCl5-mediated reactions. Polycyclic arenes like phenanthrenes, triphenylenes, chrysenes, or helicenes were selectively obtained in yields up to 87% and in some cases unusual rearrangements were crucial for the product formation.

Front Cover: Electrosynthetic Screening and Modern Optimization Strategies for Electrosynthesis of Highly Value‐added Products (ChemElectroChem 14/2021)

Electrosynthetic screening and modern optimization strategies for electrosynthesis of highly value-added products

Get into flow: Design of experiments as a key technique in the optimization of anodic dehydrogenative C,C cross-coupling reaction of phenols in flow electrolyzers

Abstract The optimization of electro-organic reactions poses a challenge due to the various parameters involved. Quite often those parameters are not independent from each other, leading the experimental scientist using linear approaches into an optimization loophole. We report a strategy for the optimization of the anodic oxidative dehydrogenative C,C cross-coupling reactions for the synthesis of biphenols based on Design of Experiments (DoE), which overcomes the drawbacks of linear optimization approaches. Using a fractional design, we increased the yield of a long-time investigated example reaction from 44% up to 85% and point out different suitable reaction conditions through to linear …

CCDC 1882077: Experimental Crystal Structure Determination

Related Article: Sebastian B. Beil, Peter Franzmann, Timo Müller, Maximilian M. Hielscher, Tobias Prenzel, Dennis Pollok, Nicole Beiser, Dieter Schollmeyer, Siegfried R. Waldvogel|2018|Electrochimica Acta|302|310|doi:10.1016/j.electacta.2019.02.041

CCDC 1882075: Experimental Crystal Structure Determination

Related Article: Sebastian B. Beil, Peter Franzmann, Timo Müller, Maximilian M. Hielscher, Tobias Prenzel, Dennis Pollok, Nicole Beiser, Dieter Schollmeyer, Siegfried R. Waldvogel|2018|Electrochimica Acta|302|310|doi:10.1016/j.electacta.2019.02.041

CCDC 1882076: Experimental Crystal Structure Determination

Related Article: Sebastian B. Beil, Peter Franzmann, Timo Müller, Maximilian M. Hielscher, Tobias Prenzel, Dennis Pollok, Nicole Beiser, Dieter Schollmeyer, Siegfried R. Waldvogel|2018|Electrochimica Acta|302|310|doi:10.1016/j.electacta.2019.02.041

CCDC 1882073: Experimental Crystal Structure Determination

Related Article: Sebastian B. Beil, Peter Franzmann, Timo Müller, Maximilian M. Hielscher, Tobias Prenzel, Dennis Pollok, Nicole Beiser, Dieter Schollmeyer, Siegfried R. Waldvogel|2018|Electrochimica Acta|302|310|doi:10.1016/j.electacta.2019.02.041

CCDC 1882074: Experimental Crystal Structure Determination

Related Article: Sebastian B. Beil, Peter Franzmann, Timo Müller, Maximilian M. Hielscher, Tobias Prenzel, Dennis Pollok, Nicole Beiser, Dieter Schollmeyer, Siegfried R. Waldvogel|2018|Electrochimica Acta|302|310|doi:10.1016/j.electacta.2019.02.041

CCDC 1882078: Experimental Crystal Structure Determination

Related Article: Sebastian B. Beil, Peter Franzmann, Timo Müller, Maximilian M. Hielscher, Tobias Prenzel, Dennis Pollok, Nicole Beiser, Dieter Schollmeyer, Siegfried R. Waldvogel|2018|Electrochimica Acta|302|310|doi:10.1016/j.electacta.2019.02.041