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RESEARCH PRODUCT
Get into flow: Design of experiments as a key technique in the optimization of anodic dehydrogenative C,C cross-coupling reaction of phenols in flow electrolyzers
Barbara GleedeSiegfried R. WaldvogelMaximilian M. Hielschersubject
Materials scienceLinear programmingGeneral Chemical EngineeringDesign of experiments02 engineering and technologyParameter space010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesCoupling reaction0104 chemical sciencesAnodeYield (chemistry)Linear regressionElectrochemistryPoint (geometry)0210 nano-technologyBiological systemdescription
Abstract The optimization of electro-organic reactions poses a challenge due to the various parameters involved. Quite often those parameters are not independent from each other, leading the experimental scientist using linear approaches into an optimization loophole. We report a strategy for the optimization of the anodic oxidative dehydrogenative C,C cross-coupling reactions for the synthesis of biphenols based on Design of Experiments (DoE), which overcomes the drawbacks of linear optimization approaches. Using a fractional design, we increased the yield of a long-time investigated example reaction from 44% up to 85% and point out different suitable reaction conditions through to linear regression of the parameter space investigated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-01 | Electrochimica Acta |