0000000000361815
AUTHOR
Francisco Cabezuelo
Vitamin A deficiency causes oxidative damage to liver mitochondria in rats.
Mitochondrial damage in rat liver induced by chronic vitamin A-deficiency was studied using three different groups of rats: (i) control rats, (ii) rats fed a vitamin A-free diet until 50 d after birth and (iii) vitamin A-deficient rats re-fed a control diet for 30 d. No statistical difference in body weight and food intake was found between control and vitamin A-deficient rats. Liver GSH concentration was similar in both groups. However, in vitamin A-deficient rats, the mitochondrial GSH/GSSG ratio was significantly lower and the levels of malondialdehyde (MDA) and 8-oxo-7, 8-dihydro-2'-deoxyguanosine (oxo8dG) were higher when compared to control rats. These values were partially restored i…
Vitamin A Deficiency Increases Protein Catabolism and Induces Urea Cycle Enzymes in Rats
Chronic vitamin A deficiency induces a substantial delay in the rates of weight and height gain in both humans and experimental animals. This effect has been associated with an impaired nutrient metabolism and loss of body protein. Therefore, we analyzed the effect of vitamin A deficiency on endogenous proteolysis and nitrogen metabolism and its reversibility with all-trans retinoic acid (RA). Male weanling rats, housed in pairs, were pair-fed a vitamin A-deficient (VAD) or control diet until they were 60 d old. A group of deficient rats were further treated with daily intraperitoneal injections of all-trans RA for 10 d. Final body and tissue (i.e. liver and heart) weights were significantl…
La guia docent com a eina activa en la praxi didàctica de matèries de Publicitat i RRPP adaptades a l’EEES
El presente estudio recoge la aplicación y adaptación a los principios del EEES de la herramienta "Guía Docente" en tres asignaturas propias de los estudios en Publicidad y RR.PP.: Creatividad Publicitaria, Relaciones Públicas y Empresa Comunicativa.