0000000000362341

AUTHOR

Magda Monari

showing 7 related works from this author

Ru(bpy)2Cl2: A catalyst able to shift the course of the photorearrangement in the Boulton-Katritzky reaction

2015

The Boulton-Katritzky reaction represents one of the most popular and efficient strategies used to realize azole-into-azole conversions. For example, under different experimental conditions, it allows the rearrangement of Z-arylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazoles (1) into 2-aryl-4-benzoylamino-5-phenyl-2H-1,2,3-triazoles (2) in very high yields. Moreover, we have recently realized this conversion also by UV-photostimulation. Now we have enlarged the scope of the reaction irradiating with visible or UV light an acetonitrile solution of some Z-arylhydrazones (1a-e) in the presence of catalytic amounts of Ru(bpY)(2)Cl-2. We have observed the unexpected formation of the 1-aryl-5-…

RegiochemistryRuthenium catalystDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistryRegioselectivityRuthenium catalystPhotochemistryDFTBiochemistryCatalysischemistry.chemical_compoundchemistryPhotochemical rearrangementDrug Discovery124-OxadiazoleAcetonitrile
researchProduct

Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization an…

2016

The synthesis and characterization of twenty new pentamethylcyclopentadienyl-rhodium and iridium complexes containing N^N and N^O-chelating chloroquine analogue ligands are described. The in vitro antimalarial activity of the new ligands as well as the complexes was evaluated against the chloroquine sensitive (CQS) NF54 and the chloroquine resistant (CQR) Dd2 strains of Plasmodium falciparum. The antimalarial activity was found to be good to moderate; although all complexes are less active than artesunate, some of the ligands and complexes showed better activity than chloroquine (CQ). In particular, rhodium complexes were found to be considerably more active than iridium complexes against t…

Models Molecularantimalarial propertiesStereochemistryPlasmodium falciparumDrug ResistanceMolecular Conformationchemistry.chemical_elementCrystal structureChemistry Techniques Synthetic010402 general chemistryIridiumLigands01 natural sciencesChlorideRhodiumIridium and Rhodium complexes chloroquine analog ligands Crystal structures in vitro antimalarian activityInorganic Chemistrychemistry.chemical_compoundAntimalarialsmedicineOrganometallic CompoundsMoietyRhodiumIridiumta116iridium complexesGroup 2 organometallic chemistrySchiff basechloroquine analogue ligands010405 organic chemistrypentamethylcyclopentadienyl-rhodium complexesChloroquine0104 chemical scienceschemistryDerivative (chemistry)medicine.drug
researchProduct

ChemInform Abstract: Ru(bpy)2Cl2: A Catalyst Able to Shift the Course of the Photorearrangement in the Boulton-Katritzky Reaction.

2016

Abstract The Boulton–Katritzky reaction represents one of the most popular and efficient strategies used to realize azole-into-azole conversions. For example, under different experimental conditions, it allows the rearrangement of Z-arylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazoles (1) into 2-aryl-4-benzoylamino-5-phenyl-2H-1,2,3-triazoles (2) in very high yields. Moreover, we have recently realized this conversion also by UV-photostimulation. Now we have enlarged the scope of the reaction irradiating with visible or UV light an acetonitrile solution of some Z-arylhydrazones (1a–e) in the presence of catalytic amounts of Ru(bpy)2Cl2. We have observed the unexpected formation of the 1-a…

chemistry.chemical_compoundChemistryTriazole derivativesGeneral MedicinePhotochemistryAcetonitrileCatalysisChemInform
researchProduct

CCDC 1426907: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

Space GroupCrystallographyCrystal System(eta5-pentamethylcyclopentadienyl)-(N-(7-chloroquinolin-4-yl)-N'-(pyridin-2-ylmethylene)ethane-12-diamine)-chloro-iridium(iii) chloride trihydrateCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1426908: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

Space GroupCrystallographyCrystal SystemCrystal Structure(eta5-pentamethylcyclopentadienyl)-(4-chloro-2-(((2-((7-chloroquinolin-4-yl)amino)ethyl)imino)methyl)phenolato)-chloro-rhodium(iii) dichloromethane solvateCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1426906: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

(eta5-pentamethylcyclopentadienyl)-(N-(7-chloroquinolin-4-yl)-N'-(pyridin-2-ylmethyl)ethane-12-diamine)-chloro-rhodium(iii) chloride dichloromethane solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1029103: Experimental Crystal Structure Determination

2015

Related Article: Maurizio D’Auria, Vincenzo Frenna, Magda Monari, Antonio Palumbo-Piccionello, Rocco Racioppi, Domenico Spinelli, Licia Viggiani|2015|Tetrahedron Lett.|56|6598|doi:10.1016/j.tetlet.2015.10.030

Space GroupCrystallographyN-(1-(3-Methylphenyl)-3-phenyl-1H-124-triazol-5-yl)benzamideCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct