Surface Plasmon Resonance Optical Biosensors for Mannoproteins Detection

Antiblastic drug combinations with ifosfamide: an update

Ifosfamide is an alkylating agent that is widely used in the treatment of various neoplasms, such as sarcomas, lymphomas, pediatric malignancies, germ cell tumors, lung, breast and ovarian cancer. The clinical toxicity of ifosfamide depends on the dose and administration schedules. The pharmacologic features of this drug enable its combination with other antiblastic agents, such as vinorelbine, gemcitabine, paclitaxel and docetaxel. Moreover, the pharmacologic profile of ifosfamide allows the use of this antiblastic drug in patients who have previously failed many other treatments, and a large percentage of responses has already been obtained. There is some concern about the optimal schedul…

Liquid Biopsy in Gastrointestinal Stromal Tumor

Over the past 15 years, gastrointestinal stromal tumors (GISTs) have emerged from a poorly understood neoplasm to a well-defined tumor entity. Starting from 2000, the discovery of gain-of-function mutations involving KIT or PDGFRα (platelet-derived growth factor-α) genes and the development of tyrosine kinase inhibitors (TKIs), such as imatinib, revolutionized dramatically the management of GISTs. Due to the almost continual emergence of new data about biological complexity of GISTs and more sophisticated whole-genome technologies, to date, the role of molecular biology is clinically important to drive therapeutic decision making. The possibility of using liquid biopsy in GISTs was reported…

Design, realization, and testing of a SPR biosensing system for wine quality monitoring

A complete innovative and portable, for on-field operation, Surface Plasmon Resonance (SPR) biosensing system for wine quality monitoring was designed, realized and tested; the system takes advantage of the innovative module Spreeta™, an integrated transducer designed by Texas Instruments able to recognize the Surface Resonance Phenomena and to represent it through electrical signals. The system, based on an 8 bit microprocessor board, acquires through a 12 bit A/D converter, elaborates and sends to a PC data from the Spreeta™ sensor. A proprietary high-level software calculates the refractive index related to biological solution flowing on the surface sensor and lets to detect suitable sub…