showing 3 related works from this author
Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374]
2004
Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374] Volkmar Lessmann a,∗, Kurt Gottmann b, Marzia Malcangio c a Department of Physiology and Pathophysiology, Johannes Gutenberg-University Mainz, Duesbergweg 6, Room 03/619, Mainz 55128, Germany b Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany c Sensory Function, Centre for Neuroscience, King’s College, London, UK
Neurotrophin secretion: current facts and future prospects
2003
The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) were originally identified as neuronal survival factors. During the last decade, evidence has accumulated implicating them (especially BDNF) in addition in the regulation of synaptic transmission and synaptogenesis in the CNS. However, a detailed understanding of the secretion of neurotrophins from neurons is required to delineate their role in regulating synaptic function. Some crucial questions that need to be addressed include the sites of neurotrophin secretion (i.e. axonal versus dendritic; synaptic versus extrasyna…
A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors.
2003
Recent evidence indicates that trophic factors can exert fast effects on neurones and so alter synaptic plasticity. Here, we focus on brain-derived neurotrophic factor (BDNF), which exerts a modulatory action at hippocampal synapses that are involved in learning and memory, and at the first pain synapse between primary sensory neurones and dorsal horn neurones. Hippocampal and sensory neurones share some properties for the release of endogenous BDNF. In the Schaffer collateral pathway of the hippocampus, binding of BDNF to high-affinity trkB receptors is essential for the induction of long-term potentiation, a specific type of synaptic plasticity. However, the consequences of BDNF binding t…