0000000000364911

AUTHOR

Kurt Gottmann

showing 3 related works from this author

Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374]

2004

Erratum to “Neurotrophin secretion: current facts and future prospects” [Progr. Neurobiol. 69 (2003) 341–374] Volkmar Lessmann a,∗, Kurt Gottmann b, Marzia Malcangio c a Department of Physiology and Pathophysiology, Johannes Gutenberg-University Mainz, Duesbergweg 6, Room 03/619, Mainz 55128, Germany b Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany c Sensory Function, Centre for Neuroscience, King’s College, London, UK

Sensory functionCell physiologybiologyGeneral Neurosciencebiology.proteinNeuroscienceNeurotrophinProgress in Neurobiology
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Stably BDNF-GFP expressing embryonic stem cells exhibit a BDNF release-dependent enhancement of neuronal differentiation

2013

Brain-derived neurotrophic factor (BDNF) is known to be a crucial regulator of neuronal survival and synaptic plasticity in the mammalian brain. Furthermore, BDNF positively influences differentiation of embryonic neural precursors as well as of neural stem cells from adult neurogenic niches. To study the impact of cell-released BDNF on neural differentiation of embryonic stem cells (ESCs), which represent an attractive source for cell transplantation studies, we have generated BDNF-GFP overexpressing mouse ESC clones by knock-in technology. After neural differentiation in vitro, we observed that BDNF-GFP overexpressing ESC clones gave rise to an increased number of neurons as compared to c…

Brain-derived neurotrophic factorCell BiologyAnatomyBiologyEmbryonic stem cellNeural stem cellCell biologyGreen fluorescent proteinTransplantationnervous systemNeurotrophic factorsembryonic structuresSynaptic plasticityGABAergicJournal of Cell Science
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Neurotrophin secretion: current facts and future prospects

2003

The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) were originally identified as neuronal survival factors. During the last decade, evidence has accumulated implicating them (especially BDNF) in addition in the regulation of synaptic transmission and synaptogenesis in the CNS. However, a detailed understanding of the secretion of neurotrophins from neurons is required to delineate their role in regulating synaptic function. Some crucial questions that need to be addressed include the sites of neurotrophin secretion (i.e. axonal versus dendritic; synaptic versus extrasyna…

Central Nervous SystemNeuronsNeuronal PlasticityArc (protein)biologyCell SurvivalGeneral NeuroscienceSynaptogenesisLong-term potentiationAMPA receptorNeurotransmissionCell Linenervous systemNeurotrophic factorsTrk receptorbiology.proteinAnimalsHumansNerve Growth FactorsPeptidesNeuroscienceForecastingNeurotrophinProgress in Neurobiology
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