0000000000365261
AUTHOR
U. Martin
Dose-dependent absorption and elimination of cefadroxil in man.
The pharmacokinetic behaviour of cefadroxil was dose-dependent in healthy male volunteers following the oral administration of single doses of 5, 15, and 30 mg.kg-1. As the dose of cefadroxil increased from 5 to 15 and 30 mg.kg-1, the peak plasma concentrations, normalized to 5 mg.kg-1, decreased significantly from 15.1 to 10.7 and 7.6 mg.l-1, while the corresponding normalized areas under the plasma concentration-time curves from 0 to 2 h decreased significantly from 1258 to 946 and 801 min.mg.l-1. When the same subjects were given 5 mg.kg-1 of cefadroxil together with 45 mg.kg-1 of cephalexin, the absorption of cefadroxil was slowed to a similar or greater extent than with the high dose o…
The Early Palaeozoic break-up of northern Gondwana, new palaeomagnetic and geochronological data from the Saxothuringian Basin, Germany
Early Palaeozoic volcanic and sedimentary rocks from the Saxothuringian Basin (Franconian Forest, northern Bavaria) have been subjected to detailed radiometric and palaeomagnetic studies in order to determine the tectonic environment and geographic setting in which they were deposited. Two hand samples were collected from the as yet undated pyroclastic flow deposits for 207Pb/206Pb age dating. Radiometric results for these samples, obtained by the single-zircon evaporation technique, are identical within error, and the mean age of all measured grains is 478.2±1.8 Ma (n=11). This age is considered to be primary and firmly constrains the eruption of the ignimbrites and formation of the subaqu…