0000000000365395

AUTHOR

Jeremy Skrzypski

showing 2 related works from this author

Effect of dietary polyunsaturated fatty acids on the expression of peroxisomal ABC transporters

2008

Abstract Peroxisomal ABC transporters encoded by the ABCD genes are thought to participate in the import of specific fatty acids in the peroxisomal matrix. ABCD1 deficiency is associated with X-linked adrenoleukodystrophy (X-ALD), the most frequent peroxisomal disorder which is characterized by the accumulation of saturated very-long-chain fatty acids (VLCFA). ABCD2 (the closest homolog of ABCD1) and ABCD3 have been shown to have partial functional redundancy with ABCD1; only when overexpressed, they can compensate for VLCFA accumulation. Other lipids, for instance polyunsaturated fatty acids (PUFA), should be possible candidate substrates for the ABCD2 and ABCD3 gene products, ALDRP and PM…

MaleATP-binding cassette transporterBiologyBiochemistryDietary Fats UnsaturatedAdrenal GlandsPeroxisomal disorderPeroxisomesmedicineAnimalsPPAR alphachemistry.chemical_classificationReverse Transcriptase Polymerase Chain ReactionPeroxisomal matrixBrainGeneral MedicinePeroxisomemedicine.diseaseRatsGene Expression RegulationLiverBiochemistrychemistryDocosahexaenoic acidFatty Acids UnsaturatedACOX1ATP-Binding Cassette TransportersAdrenoleukodystrophyOxidation-ReductionPolyunsaturated fatty acidBiochimie
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Revisiting delta-6 desaturase regulation by C18 unsaturated fatty acids, depending on the nutritional status.

2009

Dietary polyunsaturated fatty acids (PUFA) play a key role in regulating delta-6 desaturase (D6D), the key enzyme for long-chain PUFA biosynthesis. Nevertheless, the extent of their effects on this enzyme remains controversial and difficult to assess. It has been generally admitted that C18 unsaturated fatty acids (UFAs) regulate negatively delta-6 desaturase (D6D). This inhibition has been evidenced in regard to a high glucose/fat free (HG/FF) diet used in reference. However, several nutritional investigations did not evidence any inhibition of desaturases when feeding fatty acids. Because the choice of the basal diet appeared to be of primary importance in such experiments, our goal was t…

chemistry.chemical_classificationalpha-Linolenic acidLinoleic acidGeneral MedicineBiologyBiochemistryDietary FatsLinoleoyl-CoA DesaturaseDelta-6-desaturaseRatschemistry.chemical_compoundOleic acidVegetable oilBiochemistrychemistryBiosynthesisGene Expression RegulationFatty Acids Omega-3Fatty Acids UnsaturatedAnimalsHumansSpecific activityFood scienceRats WistarPolyunsaturated fatty acidBiochimie
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