Oligonucleotide-capped mesoporous silica nanoparticles as DNA-responsive dye delivery systems for genomic DNA detection

2015

[EN] New hybrid oligonucleotide-capped mesoporous silica nanoparticles able to detect genomic DNA were designed.

A Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP

2014

The synthesis, characterization and sensing features of a novel probe 1 for the selective chromogenic recognition of diisopropylfluorophosphate (DFP), a sarin and soman mimic, in 99:1 (v/ v) water/acetonitrile and in the gas phase is reported. Colour modulation is based on the combined reaction of phosphorylation of 1 and fluoride-induced hydrolysis of a silyl ether moiety. As fluoride is a specific reaction product of the reaction between DFP and the OH group, the probe shows a selective colour modulation in the presence of this chemical. Other nerve agent simulants, certain anions, oxidant species and other organophosphorous compounds were unable to induce colour changes in 1. This is one…

Acetylcholinesterase-Capped Mesoporous Silica Nanoparticles That Open in the Presence of Diisopropylfluorophosphate (a Sarin or Soman Simulant)

2016

Mesoporous silica nanoparticles loaded with rhodamine B and capped with acetylcholinesterase are able to be selectively opened and deliver their cargo in the presence of nerve agent simulant diisopropyl fluorophosphate (DFP).

A voltammetric e-tongue tool for the emulation of the sensorial analysis and the discrimination of vegetal milks

2018

[EN] The relevance of plant-based food alternatives to dairy products, such as vegetable milks, has been growing in recent decades, and the development of systems capable of classifying and predicting the sensorial profile of such products is interesting. In this context, a methodology to perform the sensorial analysis of vegetable milks (oat, soya, rice, almond and tiger nut), based on 12 parameters, was validated. An electronic tongue based on the combination of eight metals with pulse voltammetry was also tested. The current intensity profiles are characteristic for each non-dairy milk type. Data were processed with qualitative (PCA, dendrogram) and quantitative (PLS) tools. The PCA stat…

Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

2012

[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. In the first step, the pores of an inorganic MCM-41 support (in the form of nanoparticles) were loaded with [Ru(bipy) 3]Cl 2 complex, and then, in the second step, the pore outlets were functionalized with ester glycol moieties that acted as molecular caps. In the absence of an enzyme, release of the complex from aqueous suspensions of S1 at pH 8.0 is inhibited due to the steric hindrance imposed by the bulky ester glycol moieties. Upon addition of esterase enzyme, del…

Chromogenic Detection of Aqueous Formaldehyde Using Functionalized Silica Nanoparticles

2016

Silica nanoparticles functionalized with thiol reactive units and bulky polar polyamines were used for the selective colorimetric detection of formaldehyde. The reaction of thiols groups in the nanoparticles surface with a squaraine dye resulted in loss of the pi-conjugation of the chromophores, and the subsequent bleaching of the solution. However, when formaldehyde was present in the suspension, the thiol-squaraine reaction was inhibited and a chromogenic response was observed. A selective response to formaldehyde was observed only when the thiol and polyamine groups were anchored to the silica surface. The observed selective response was ascribed to the fact that bulky polyamines generat…

Materials per a lautoaprenentatge pràctic en Genètica: problemes interactius

2012

Taula rodona d'experiències d'innovació Educativa de la Universitat de València. Producción:CREAM (htto://cream.uv.es)-SFPIE (www.uv.es/sfpie)-VLC Campus

Projecte DocenTIC ''Grup per la Elaboració de Materials Educatius de Genètica (GEMEG)''

Entrevista a Lluís Pascual Calaforra (Professor Titular de la Universitat de València i coordinador del Grup per la Elaboració de Materials Educatius de Genètica GEMEG'') on presenta el materials elaborats com problemes autoexplicatius i interactius pel seu grup d'innovació educativa''; Producció: Servei de Formació Permanent i Innovació Educativa (http://www.uv.es/sfpie) i el Centre de Recursos Educatius i Aprenentatge Multimèdia (http://cream.uv.es);

Taller Tics aplicadas a la docencia en genética

2011

Distintas herramientas 2.0 aplicadas a la docencia de Genética.Producción: CREAM. http://cream.uv.es

XIMET – The Trans-University Educational Materials Exchange-Network with a Focus on Genetics

2013

XiMET (Xarxa d'intercanvi de Materials Educatius Transuniversitària) es una red de innovación educativa y calidad docente formada por profesorado perteneciente a las Universidades de Valencia (UVEG), Universidad Politécnica de Valencia (UPV), la Universidad de Barcelona (UB) y la Universidad Autónoma de Madrid (UAM). Dicha red se ha establecido para la difusión de las acciones realizadas por el profesorado del departamento de Genética de la UVEG dentro de los grupos GEMEG y BIOPAC, y además facilitar la activación de alianzas de innovación interuniversitaria. Una tarea fundamental de XiMET es la elaboración de materiales docentes y objetos de aprendizaje multimedia, diseñados como apoyo par…