0000000000368565

AUTHOR

Steven Black

showing 2 related works from this author

Incidence rates of narcolepsy diagnoses in Taiwan, Canada, and Europe: The use of statistical simulation to evaluate methods for the rapid assessment…

2018

Vacunación; Narcolepsia; Simulación y modelado: en Vacunació; Narcolèpsia; Simulació i modelització Vaccination; Narcolepsy; Simulation and modeling Background & objectives Vaccine safety signals require investigation, which may be done rapidly at the population level using ecological studies, before embarking on hypothesis-testing studies. Incidence rates were used to assess a signal of narcolepsy following AS03-adjuvanted monovalent pandemic H1N1 (pH1N1) influenza vaccination among children and adolescents in Sweden and Finland in 2010. We explored the utility of ecological data to assess incidence of narcolepsy following exposure to pandemic H1N1 virus or vaccination in 10 sites that use…

Male:Other subheadings::Other subheadings::/epidemiology [Other subheadings]medicine.medical_treatmentlcsh:Medicine:Other subheadings::Other subheadings::/drug therapy [Other subheadings]medicine.disease_causeGeographical locations:enfermedades del sistema nervioso::trastornos del sueño-vigilia::disomnias::trastornos intrínsecos del sueño::trastornos de somnolencia excesiva::narcolepsia [NarcolepsiaENFERMEDADES]Influenza A Virus H1N1 Subtype0302 clinical medicineRisk FactorsPandemicMedicine and Health SciencesInfluenza A virusMedicinePublic and Occupational Health030212 general & internal medicineYoung adultChildlcsh:Science:Otros calificadores::Otros calificadores::/tratamiento farmacológico [Otros calificadores]Aged 80 and overVaccinesMultidisciplinaryIncidenceSimulation and ModelingIncidence (epidemiology)Vaccination:Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores]Middle AgedVaccination and ImmunizationEuropeVaccinationInfectious DiseasesNeurologyInfluenza VaccinesChild PreschoolsymbolsEngineering and TechnologyFemaleSafetyNarcolèpsia - TractamentAdjuvantResearch ArticleAdultCanadaAsiaAdolescentInfectious Disease ControlImmunologyTaiwanResearch and Analysis MethodsYoung Adult03 medical and health sciencessymbols.namesakeAdjuvants ImmunologicEnvironmental healthInfluenza HumanHumansComputer SimulationEuropean UnionPoisson regressionAgedTrastorns del sonNarcolepsySwedenModels Statisticalbusiness.industrylcsh:RInfant NewbornNarcolèpsia - EpidemiologiaInfantBiology and Life SciencesDyssomniasAge GroupsR - MedicineRelative riskSignal ProcessingPopulation Groupingslcsh:QPreventive MedicinePeople and placesSleep Disordersbusiness030217 neurology & neurosurgeryPLOS ONE
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Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer?

2005

Objective—Human C-reactive protein (CRP) was reported to accelerate atherosclerotic lesion development in male but not in female apolipoprotein E (apoE) knockout mice. Here, mice expressing rabbit CRP (rbCRP) were crossbred onto apoE knockout animals, and the effect on atherogenesis was studied.Methods and Results—Hemolytic complement activity could not be detected in apoE knockout mice. Furthermore, in contrast to human complement, neither rabbit nor human CRP complexed to modified low-density lipoprotein–activated murine complement. At 52 weeks, rbCRP levels were similar in male and female transgenic animals. Serum cholesterol levels were equivalent in female animals irrespective of rbCRP…

Apolipoprotein EMalemedicine.medical_specialtyPathologyRatónTransgeneHypercholesterolemiaMice TransgenicLesionMiceApolipoproteins ESpecies SpecificityInternal medicinemedicineAnimalsHumansTransgenesAortaMice KnockoutbiologyVascular diseaseC-reactive proteinCholesterol LDLComplement System Proteinsmedicine.diseaseAtherosclerosisComplement systemMice Inbred C57BLDisease Models AnimalEndocrinologyC-Reactive ProteinKnockout mousebiology.proteinFemaleDietary ProteinsRabbitsmedicine.symptomCardiology and Cardiovascular MedicineArteriosclerosis, thrombosis, and vascular biology
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