Solvates of Dasatinib: Diversity and Isostructurality

A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I …

The influence of pH on the stability of antazoline: kinetic analysis

Degradation of the drug antazoline was studied in aqueous solutions by means of pH-rate profiling (pH 0–7.4). The novel approach of Runge–Kutta numerical integration in combination with multi-parameter optimisation was applied to UV-Vis spectral data to determine a valid kinetic model and kinetic parameters of the degradation process. The overall degradation mechanism was found to be dependent on the environmental pH. In the pH range of 3.0–7.4, the formation of the antazoline hydrolysis product (N-(2-aminoethyl)-2-(N-benzylanilino)acetamide) through three different pathways (acidic, non-catalysed, and semi-alkaline hydrolysis) was observed. In highly acidic media (pH 0–2), the degradation …

Kapitāla augļi kā ražošanas izmaksa

Saturs (nodaļas): I. Ievads. II. Vai kapitāla augļi ir izmaksas sastāvdaļa? III. Kapitāla augļi pašizmaksas un rezultātu aplēsēs. IV. Kapitāla augļu kā izmaksas sastāvdaļas aplēšana un grāmatošana. V. Slēdziens. Die Kapitalzinsen als Produktionskosten (Zusammenfassung)

Furazidīna stabilitāte šķīdumos

Furazidīna stabilitāte šķīdumos. Bērziņš K., zinātniskais vadītājs Prof. Dr. ķīm. Andris Actiņš, konsultants Mag. ķīm. Ilze Grante, Maģistra darbs, 41 lapaspuse, 21 attēls, 8 tabulas, 43 literatūras avoti, 4 pielikumi. Latviešu valodā. Literatūras apskatā apkopota informācija par farmaceitiski aktīvo vielu degradāciju un to pētīšanas metodēm šķīdumos – UV/VIS spektroskopiju un augsti efektīvo šķīdrumu hromatogrāfiju-masspektrometriju; kompleksu sistēmu reakciju kinētiku homogēnā vidē. Veikti spektroskopiski furazidīna degradācijas pētījumi etanolā un bāziskos ūdens šķīdumos; hromatogrāfiski pētīta furazidīna bāzisku ūdens šķīdumu degradācijas dinamika un veikta komponentu kvalitatīvā analīz…

Latvijas Universitātes tautsaimniecības un tiesību zinātņu fakultātes bibliotēkas sistēmatiskais katalogs, 1. sēj.

Multi-technique approach for qualitative and quantitative characterization of furazidin degradation kinetics under alkaline conditions

Degradation of drug furazidin was studied under different conditions of environmental pH (11-13) and temperature (30-60°C). The novel approach of hybrid hard- and soft-multivariate curve resolution-alternating least squares (HS-MCR-ALS) method was applied to UV-vis spectral data to determine a valid kinetic model and kinetic parameters of the degradation process. The system was found to be comprised of three main species and best characterized by two consecutive first-order reactions. Furazidin degradation rate was found to be highly dependent on the applied environmental conditions, showing more prominent differences between both degradation steps towards higher pH and temperature. Complim…

CCDC 910846: Experimental Crystal Structure Determination

Related Article: Kārlis Bērziņš, Artis Kons, Ilze Grante, Diana Dzabijeva, Ilva Nakurte, Andris Actiņš|2016|J.Pharm.Biomed.Anal.|129|433|doi:10.1016/j.jpba.2016.07.039

CCDC 1420813: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

CCDC 1420812: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

CCDC 1420811: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

CCDC 1420810: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

CCDC 1420814: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

CCDC 1420809: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

CCDC 910834: Experimental Crystal Structure Determination

Related Article: Kārlis Bērziņš, Artis Kons, Ilze Grante, Diana Dzabijeva, Ilva Nakurte, Andris Actiņš|2016|J.Pharm.Biomed.Anal.|129|433|doi:10.1016/j.jpba.2016.07.039

CCDC 1420807: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

CCDC 1420808: Experimental Crystal Structure Determination

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024